attention
Visit DoctorOnCall Singapore
💉 Wegovy is now available! Start your weight-loss journey today. Limited quantities available — don't miss out! Order Today

Points

Reorder

0

Cart

Account

COVID-19 Saliva Self-Test Kit
COVID-19 Test
Health Screening
COVID-19 Vaccine
Blood Pressure Control
Cholesterol Management
Blood Pressure Control
Pain Relief
Men's Condition
Family Planning
Vitamins A-Z
Search History
Clear History
Cart History
Clear History
BM

Voucher Redeemed!

Voucher will be automatically applied upon checkout

*Limited to 1 use per customer only

*DOC reserves the right to reverse the voucher redemption and cancel any orders associated if the code is used more than once

Diane-35 Tablet 21s - DoctorOnCall Online Pharmacy
Diane-35 Tablet 21s - DoctorOnCall Online Pharmacy
Diane-35 Tablet 21s - DoctorOnCall Online Pharmacy Diane-35 Tablet 21s - DoctorOnCall Online Pharmacy

Diane-35 Tablet 21s

Prescription Required

CLOSE
Prescription Required
This medication requires a valid prescription from a doctor.
Don’t Have A Prescription? Get A Consult With Our Doctor Today.
STEP 1
Checkout & review your order.
STEP 2
Make payment.
STEP 3
Our doctor will contact you within 1-hour of your purchase.
RM 71.87
RM 56.00
1106 people have already bought this
ic_fluent_signed_24_filledCreated with Sketch. 100% Authentic
Muslim Friendly
Voucher
CLOSE
Prescription Required
This medication requires a valid prescription from a doctor.
Don’t Have A Prescription? Get A Consult With Our Doctor Today.
STEP 1
Checkout & review your order.
STEP 2
Make payment.
STEP 3
Our doctor will contact you within 1-hour of your purchase.
Term & Condition
100% Authentic
We ensure that all our pharmaceutical products including health supplements and traditional preparations are registered with the National Pharmaceutical Regulatory Authority (NPRA) Malaysia
Free Delivery on orders above RM120
Enjoy free delivery with a minimum spend of RM120 on our platform.
Quantity
Only 48 left - hurry!
Maximum 3 units per Customer

Daily Operational Hours for consultations:
8:00AM to 8.00PM

CLOSE
Prescription Required
This medication requires a valid prescription from a doctor.
Don’t Have A Prescription? Get A Consult With Our Doctor Today.
STEP 1
Checkout & review your order.
STEP 2
Make payment.
STEP 3
Our doctor will contact you within 1-hour of your purchase.
Term & Condition
100% Authentic
We ensure that all our pharmaceutical products including health supplements and traditional preparations are registered with the National Pharmaceutical Regulatory Authority (NPRA) Malaysia
Free Delivery on orders above RM120
Enjoy free delivery with a minimum spend of RM120 on our platform.

Product Overview

Introduction of Diane-35 Tablet 21s

Diane-35 is a well-known combination oral tablet belonging to the anti-androgen and hormonal contraceptive drug class, containing the active ingredients cyproterone acetate (2 mg) and ethinylestradiol (35 mcg). If you are considering this tablet, it is important to know that like most hormonal medications, it may come with some side effects — the most commonly reported ones include nausea, headache, mood changes, and breast tenderness. Some users may also experience changes in their menstrual cycle or fluid retention during the initial weeks of use. This is a prescription-based medication, so we always encourage you to consult your doctor or pharmacist before starting or stopping it. Rest assured, when used correctly under medical supervision, Diane-35 has a well-established safety profile that has been trusted by healthcare providers for many years.

How to Take Diane-35 Tablet

Diane-35 tablets should be taken orally, once daily, preferably at the same time each day to maintain consistent hormone levels in your body. Each pack contains 21 tablets, and you should take one tablet daily for 21 consecutive days, followed by a 7-day tablet-free break, during which a withdrawal bleed (similar to a period) usually occurs. Always swallow the tablet whole with a glass of water, and if you are unsure about when to start your first pack, your doctor or pharmacist will guide you based on your individual health profile.

Dosage of Diane-35 Tablet

The standard recommended dose of Diane-35 is one tablet per day for 21 days, followed by a 7-day break before starting the next pack. Do not take more than the prescribed dose, and always follow your doctor's specific instructions, as individual dosage guidance may vary based on your health condition and medical history.

Shelf Life of Diane-35 Tablet

Diane-35 tablets typically have a shelf life of 3 to 5 years from the date of manufacture, as indicated on the original packaging. Always check the expiry date printed on the blister pack and outer carton before use. Do not use the tablets if the expiry date has passed, even if the tablets appear physically unchanged, as the potency and safety of the active ingredients may be compromised after the stated shelf life.

How to Store Diane-35 Tablet

  • Store Diane-35 tablets at room temperature, below 25°C (77°F)
  • Keep the tablets in a cool, dry place, away from direct sunlight, heat, and humidity
  • Do not store in the bathroom or near the kitchen sink, as moisture and heat can degrade the tablets
  • Keep the tablets in their original blister packaging until use to protect them from environmental exposure
  • Store out of reach of children and pets at all times
  • If you notice any changes in the tablet's colour, texture, or smell, do not use and consult your pharmacist

Active Ingredient of Diane-35 Tablet

Active IngredientStrength
Cyproterone Acetate2 mg
Ethinylestradiol35 mcg (0.035 mg)

Cyproterone acetate is a synthetic progestogen with anti-androgenic properties, while ethinylestradiol is a synthetic form of oestrogen. Together, these two hormones form the pharmacological basis of Diane-35. The tablet also contains inactive excipients (inactive ingredients) such as lactose monohydrate, maize starch, povidone, and magnesium stearate, which help form the tablet structure.

Side Effects of Diane-35 Tablet

Like all medications, Diane-35 may cause side effects in some individuals. Not everyone will experience these, and many side effects tend to reduce after the first few cycles of use.

Common Side Effects:

  • Nausea or stomach discomfort, especially when taken on an empty stomach
  • Headache or mild migraine
  • Breast tenderness or swelling
  • Mood changes, including low mood or irritability
  • Reduced sexual drive (decreased libido)
  • Spotting or breakthrough bleeding between periods
  • Weight changes (gain or loss)
  • Fluid retention or bloating

Less Common Side Effects:

  • Skin reactions such as rash or itching
  • Contact lens intolerance (changes in corneal curvature)
  • Changes in vaginal discharge
  • Elevated blood pressure
  • Mild depression or emotional sensitivity
  • Changes in cholesterol or blood lipid levels
  • Decreased menstrual flow or absence of withdrawal bleed

Rare but Serious Side Effects (Seek Immediate Medical Attention):

  • Venous thromboembolism (VTE) — blood clots in the legs or lungs (symptoms: leg pain, swelling, sudden breathlessness)
  • Arterial thrombosis — including stroke or heart attack (symptoms: sudden severe headache, chest pain, vision disturbances, weakness on one side of the body)
  • Liver disorders — including jaundice or liver tumours (symptoms: yellowing of skin or eyes, severe abdominal pain)
  • Severe allergic reactions — including angioedema (swelling of face, lips, or throat)
  • Hypertension (significantly elevated blood pressure)

⚠️ This is not a complete list of all possible side effects. Please read the full patient information leaflet included in your pack and consult your doctor or pharmacist if you experience any unusual symptoms.

Contraindications of Diane-35 Tablet

  • History or current presence of blood clots (venous thromboembolism, deep vein thrombosis, or pulmonary embolism)
  • History of stroke or heart attack (arterial thromboembolism)
  • Ischaemic heart disease or severe or multiple cardiovascular risk factors
  • Uncontrolled high blood pressure (hypertension)
  • Diabetes mellitus with vascular complications
  • Severe or active liver disease, including liver tumours (benign or malignant)
  • Known or suspected hormone-sensitive cancers (e.g., breast cancer or endometrial cancer)
  • Undiagnosed vaginal bleeding
  • History of migraines with aura (focal neurological symptoms)
  • Hypersensitivity or allergy to cyproterone acetate, ethinylestradiol, or any excipient in the formulation
  • Pregnancy or suspected pregnancy
  • Breastfeeding mothers
  • Prolonged immobilisation (e.g., post-surgery or long-term bed rest)
  • Pancreatitis associated with severe hypertriglyceridaemia (current or historical)

⚠️ This list is not exhaustive. Your doctor or pharmacist is the best person to assess whether Diane-35 is safe and appropriate for you based on your individual health profile.

Drug & Food Interactions of Diane-35 Tablet

Drug Interactions:

  • Anticonvulsants / Anti-epileptics — such as phenytoin, carbamazepine, phenobarbital, primidone, topiramate, and oxcarbazepine
  • Antibiotics — particularly rifampicin and rifabutin (used for tuberculosis)
  • Antifungals — such as griseofulvin
  • Antiretroviral drugs (HIV medications) — including ritonavir, nelfinavir, nevirapine, and lopinavir
  • Herbal preparations — especially St. John's Wort (Hypericum perforatum), which is known to significantly reduce hormonal contraceptive effectiveness
  • Cyclosporin — Diane-35 may increase plasma levels of cyclosporin, raising the risk of toxicity
  • Lamotrigine (anti-epileptic) — hormonal contraceptives may reduce lamotrigine levels, affecting seizure control
  • Anticoagulants (blood thinners) — hormonal contraceptives may alter the effectiveness of anticoagulant therapy
  • Corticosteroids — concurrent use may increase corticosteroid plasma concentrations

Food & Lifestyle Interactions:

  • Grapefruit juice — may slightly increase ethinylestradiol levels; moderate consumption is generally acceptable but worth noting
  • Alcohol — does not directly reduce contraceptive effectiveness but may increase the risk of nausea and other side effects
  • High-fat meals — do not significantly affect absorption but taking the tablet consistently with or without food is recommended for routine adherence

💊 Always disclose your complete medication list to your healthcare provider before starting Diane-35 to avoid potential interactions.

Quick Tips for Diane-35 Tablet

  • Always take Diane-35 at the same time each day to maintain consistent hormone levels and reduce the risk of missed-dose complications
  • Do not skip doses — if you miss a tablet, refer to the patient information leaflet for specific missed-dose instructions or consult your pharmacist
  • Keep your tablets in the original blister pack until you are ready to take them to protect them from moisture and light
  • Store away from heat and humidity — avoid keeping tablets in the bathroom cabinet or car glove compartment
  • Check the expiry date on your pack before starting a new strip — never use expired medication
  • Do not share your medication with others — Diane-35 is a prescription medicine tailored to your individual health needs
  • Inform all your healthcare providers (including dentists and specialists) that you are taking Diane-35, especially before any surgery or procedure
  • Dispose of unused or expired tablets responsibly — return them to your pharmacy for proper pharmaceutical waste disposal; do not flush or throw in general waste
  • Purchase only from licensed and verified pharmacies — whether online or in-store, ensure the source is legitimate and authorised to sell prescription medicines in Malaysia
  • Keep a record of your pack start dates to help you track your 21-day cycle and 7-day break schedule accurately

Frequently Asked Questions (FAQs) About Diane-35 Tablet

Q1: Can I buy Diane-35 Tablet online in Malaysia?
Yes, Diane-35 is available for purchase through licensed online pharmacies in Malaysia. However, as it is a prescription-only medication (POM), you will need a valid prescription from a registered medical doctor before it can be dispensed to you. Our online pharmacy in Malaysia operates in full compliance with the Pharmacy Act and Drug Control Authority (DCA) regulations, ensuring that your purchase is safe, legal, and authentic.

Q2: Do I need a prescription to order Diane-35 Tablet from your online pharmacy?
Yes, a valid prescription is required to purchase Diane-35 in Malaysia. This is in line with Malaysian pharmaceutical regulations, as Diane-35 is classified as a prescription medicine. You may upload your prescription during the checkout process on our website, or our team can guide you on how to submit it securely before your order is processed.

Q3: How do I know the Diane-35 Tablet I receive is genuine and not counterfeit?
We source all our pharmaceutical products directly from authorised distributors and registered suppliers in Malaysia. Every product sold through our platform is verified for authenticity, and we only stock products that are registered with the Malaysian Drug Control Authority (DCA/NPRA). You can also verify the product registration number on the NPRA BeSSeT portal at bpfk.gov.my for your peace of mind.

Q4: How long does delivery take for Diane-35 Tablet within Malaysia?
We offer delivery across Peninsular Malaysia, Sabah, and Sarawak. Standard delivery typically takes 2 to 5 working days, while express delivery options may be available for selected areas. All orders are carefully packed to protect the integrity of the medication during transit. You will receive a tracking number once your order has been dispatched.

Q5: Is Diane-35 Tablet available in all states in Malaysia?
Yes, we deliver to all states in Malaysia, including Kuala Lumpur, Selangor, Penang, Johor, Perak, Sabah, Sarawak, and beyond. Delivery timelines may vary slightly for East Malaysia locations. Please check our delivery coverage page or contact our customer support team for specific details about your area.

Q6: What payment methods are accepted when ordering Diane-35 Tablet online?
We accept a variety of secure payment methods including online banking (FPX), credit and debit cards (Visa/Mastercard), e-wallets (Touch 'n Go eWallet, GrabPay), and bank transfers. All transactions are processed through a secure, encrypted payment gateway to protect your personal and financial information.

Q7: Can I return or get a refund for Diane-35 Tablet if there is an issue with my order?
Due to the nature of pharmaceutical products and strict storage requirements, returns are generally not accepted for medicines once they have been dispensed and delivered. However, if you receive a damaged, incorrect, or expired product, please contact our customer support team immediately with photographic evidence, and we will resolve the issue promptly in accordance with our returns and refund policy.

Q8: How will my Diane-35 Tablet be packaged for delivery?
All orders are dispatched in discreet, plain packaging to protect your privacy. The packaging is also designed to maintain the appropriate storage conditions for the medication during transit. Your order details will not be visible on the outside of the parcel.

Q9: How do I store Diane-35 Tablet after receiving my delivery?
Upon receiving your order, store Diane-35 tablets at room temperature below 25°C, in a cool and dry place away from direct sunlight and moisture. Keep the tablets in their original blister packaging and ensure they are stored out of reach of children. Avoid storing them in the bathroom or in areas with high humidity.

Q10: What should I do if I receive Diane-35 Tablet that is close to or past its expiry date?
If you receive a product that is expired or close to expiry (within 30 days), please contact our customer service team immediately. We take product quality very seriously and will arrange for a replacement or refund as appropriate. We recommend checking the expiry date on your pack upon delivery as part of your routine.

Q11: Is it safe to order Diane-35 Tablet from an online pharmacy in Malaysia?
Yes, it is safe — provided you order from a licensed and registered online pharmacy. Always look for pharmacies that display their pharmacy licence number, require a valid prescription, and are transparent about their sourcing. Avoid purchasing from unverified social media sellers or unlicensed platforms, as counterfeit or improperly stored medicines pose serious health risks.

Q12: Can I order Diane-35 Tablet in bulk or multiple packs at once?
Yes, you may order multiple packs of Diane-35 in a single transaction, subject to the quantity permitted under your prescription. Our pharmacist team will review your order to ensure it aligns with your prescription details and Malaysian dispensing guidelines. If you need a larger supply, we recommend consulting your doctor for an appropriate prescription.

Frequently Bought Together

Brands

Bayer

Active Ingredient

cyproterone Ethinylestradiol 

Manufactured by

Bayer Co. (Malaysia) Sdn Bhd

Side Effects

As with all medications, you may experience some side effects. Not everyone experiences it. This is not a cause for concern. However, it is so that you are aware of it.

-


Abnormal sperm production, Infertility, Thromboembolic event, Enlargement of mammary gland/ gynaecomastia, Galactorrhea, Depressive mood changes, Change in hair pattern, Skin reaction, Fatigue and lethargy, Weight change, Breathlessness

Headache, Dizziness, Nausea and vomiting, Menstrual cycle disturbances, Breast discomfort, Change of weight, Change of libido, Hirsutism

Warning Precautions

Alcohol Warning (Not Advisable)

There are studies showed interaction of Diane-35 Tablet 21s with alcohol. Alcohol may reduces Diane-35 Tablet 21s efficacy. It is not advisable to consume it together. Consuming alcohol with Ethinyl Estradiol may worsen the side effects such as headache, dizziness, and nausea.

Pregnancy Warning (Not Safe - High Risk)

There is no data stating about the safety Diane-35 Tablet 21s used in pregnant women. This is because Diane-35 Tablet 21s can act as a contraceptive which should definitely not be taken by pregnant women. Ethinyl Estradiol is unsafe to use during pregnancy. Both animal and human studies have shown adverse effects on the fetus and fetal abnormalities. Please consult your doctor for more details.

Breastfeeding Warning (Limited Data)

No data suggests that Diane-35 Tablet 21s does represent a significant risk to the baby. However, Diane-35 Tablet 21s is not recommended to the children below 18 years old, thus, lactating mothers are not advisable to consume Diane-35 Tablet 21s due to a lack of data on safety.No academic reports explaining the use of Ethinyl Estradiol during lactation are available. However, the use of Ethinyl Estradiol for breastfeeding mothers is not recommended because it may reduce milk production and decrease the nutrient content in the milk.

Driving Warning (Not Advisable)

Do not drive unless you are feeling well. Diane-35 Tablet 21s may cause side effects such as fatigue and lassitude, which could affect your ability to concentrate and drive. Generally it is safe to take ethynilestradiol if you are driving. However, do not drive if you feel any side effects such as dizziness, headaches, or nausea, all of which could affect your ability to concentrate and drive.

Kidney Warning (High Risk)

Diane-35 Tablet 21s should be used with caution in patients with kidney disease as kidney is the place where excretion takes place. To avoid Diane-35 Tablet 21s toxicity, dose adjustment of Diane-35 Tablet 21s may be needed. Please consult your doctor.The use of Ethinyl Estradiol is should be safe in patients with kidney problem. Hoever, consult your doctor regarding dose adjustment if needed.

Liver Warning (Limited Data)

Use of Diane-35 Tablet 21s is not recommended in patients with liver disease because Diane-35 Tablet 21s is mainly metabolised in the liver. Dose adjustment may be needed in patients with inefficient liver to avoid any drug overdose or toxicity. Please consult your doctor. Ethinyl Estradiol should be used with caution in patients with liver disease. Dose adjustment of Ethinyl Estradiol may be needed. However, patients with liver carcinoma is contraindicated to take Ethinyl Estradiol. Please consult your doctor.

FAQ

Disclaimer

Information last updated on: Fri Apr 03 2026 07:14:07 GMT+0000 (Coordinated Universal Time) The product images shown are for illustration purposes only and may not be an exact representation of the product.

The content provided on this webpage is to provide information only, to be fully-interpreted by a medical professional, and not intended as a guide to make purchase decisions, or a substitute to advice of a medical professional. Effectiveness and side effects of medication may differ from individual to individual. We do not encourage any customer to self-diagnose and/or self-medicate. Patients should always consult a medical professional before taking or using any medication. The content provided here is non-exhaustive and may not cover all aspects of the medication. Our service should only be used to support the doctor-patient dynamic, not replace it.

The fulfilment of prescription medication is subject to our review of a prescription issued by a Malaysian Medical Council (MMC) registered doctor. If required, we will provide a tele-consult service with one of our registered panel doctors. This is not an advertisement of a medicine as such an advertisement would require prior approval from the Medicines Advertisement Board of Malaysia. Diane-35 Tablet 21s is available in many areas in Malaysia. Kuala Lumpur, Bukit Bintang, Titiwangsa, Setiawangsa, Wangsa Maju, Kepong, Segambut, Bandar Tun Razak, Cheras, Subang Jaya, Petaling Jaya, Mont Kiara, Puchong, Bandar Sunway, TTDI, Seri Kembangan, Klang, Bukit Tinggi, Damansara, Sentul, Penang, George Town, Jelutong, Gelugor, Bayan Baru, Bandar Baru Air Itam, Sungai Ara, Bukit Mertajam, Butterworth, Perai, Johor Bahru, Skudai, Bukit Indah, Gelang Patah, Senai, Pasir Gudang, Taman Daya, Taman Molek, Taman Perling, Tebrau, Danga Bay, Larkin, Nusajaya, Pontian, Masai, Setia Tropika, Desaru, Tampoi.


Diane-35 Tablet 21s is available at many places in Singapore. Ang Mo Kio, Alexandra, Admiralty, Bedok, Bishan, Bukit Batok, Bukit Merah, Bukit Panjang, Bukit Timah, Boat Quay, Buona Vista, Beach Road, Bugis, Balestier, Boon Lay, Central Area, Choa Chu Kang, Clementi, Chinatown, Commonwealt, City Hall, Clarke Quay, Changi Airport, Changi Village, Clementi Park, Dairy Farm, Eunos, East Coast, Farrer Park, Geylang, Hougang, Harbourfront, Holland, Jurong, Jurong East, Jurong West, Kallang/ Whampoa, Lim Chu Kang, Marine Parade, Marina, Macpherson, Mandai, Newton, Novena, Orchard, Pasir Ris, Punggol, Potong Pasir, Paya Lebar, Queenstown, Raffles Place, Rochor, River Valley, Sembawang, Sengkang, Serangoon, Serangoon Rd, Seletar, Tampines, Toa Payoh, Tanjong Pagar, Telok Blangah, Tanglin, Thomson, Tuas, Tengah, Upper East Coast, Upper Bukit Timah, Upper Thomson, Woodlands, West Coast, Yishun, Yio Chu Kang.
What Our Customers Say About Us See All See All
Erian Vix
5/5
Excellent service .. very informative and professional. Definitely will come back again. Highly recommended. Thanks DoctorOnCall.
Kenny Kang
5/5
Great discount on meds and very good and service from the patient care consultant.
Christine Tee Pei Yee
5/5
Consultation is good.. dont have to step out of the house for small issues and being really busy.. recommended
DOC AI