Overview
A blood clot is an important process in the mechanism of blood coagulation. However, forming a blood clot will include several other processes before a clot is formed . In the blood vessel, there are procoagulants and anti-coagulants substances. They are very crucial in preventing easy bleeding or unnecessary blood clots. However, in normal physiology, when a vessel is ruptured, the procoagulants will get activated. The platelets will start accumulate at the damaged endothelial wall. This begins with the damaged endothelial wall exposing the subendothelial collagen and attract the Von Willebrand factor to adhere to it. This Von Willebrand factor will cause the platelets to bind to it using glycoprotein 1 (GP 1). Then those platelets produce thromboxane A2 to attract more platelets aggregation. These blood clots are essential, as it is the primary way to stop bleeding. However, there are medications to prevent blood clots. A special group of medications known as anticoagulant medications such as fondaparinux, heparin, and warfarin is use to prevent any spontaneous blood clot formation.
