Overview
Myasthenia Gravis is an autoimmune disease mediated by autoantibodies to nicotinic acetylcholine receptors on the post-synaptic side of the neuromuscular junction. It affects the voluntary muscles and characterised by weakness and fatigability.Signs and Symptoms
Muscle weakness, Fatigue, Diplopia (double vision), Ptosis, Difficulty chewing, Difficulty swallowing, Proximal myopathy, Mushy or nasal quality speech, Facial weaknessCommon Causes
AutoantibodyRisk Factors
Presence of autoimmune disease, Age less than 50 years in female and more than 50 years in male, Thymic hyperplasia or atrophy or tumourInvestigation Techniques
Acetylcholine receptor antibody test, Tensilon test, Electromyography (EMG), CT scan to exclude thymomaTreatment and Prevention
Anticholinesterase, Immunosuppressive therapy, Thymomectomy
