Concor 5mg Tablet 100s

Concor 5mg Tablet is a prescription-only medicine that belongs to the cardioselective beta-1 adrenoceptor blocker drug class — more commonly known as a beta-blocker — and contains Bisoprolol Fumarate as its active ingredient, a highly selective beta-1 blocking agent manufactured by Merck KGaA and registered with Malaysia's National Pharmaceutical Regulatory Agency (NPRA). Bisoprolol is listed on the World Health Organization's List of Essential Medicines, reflecting its long-established and globally recognised clinical importance in cardiovascular medicine. Like all beta-blocker medicines, Concor 5mg can cause side effects, and the ones most commonly reported include fatigue or tiredness, dizziness, headache, and cold hands or feet — all of which are generally mild and linked to the medicine's expected effect of slowing the heart rate and reducing blood pressure. Before you start taking this tablet, there are a few important things you should be aware of: Concor 5mg must never be stopped abruptly without your doctor's guidance — doing so can trigger a rebound effect that may cause a dangerous surge in heart rate and blood pressure; you should also let your doctor know if you have asthma, significant breathing problems, or diabetes, as Bisoprolol can mask the warning signs of low blood sugar and, despite its cardioselectivity, may still affect the airways at higher doses.

How to Take Concor 5mg Tablet

Concor 5mg Tablet is taken orally — swallow the tablet whole or halved along the score line if half a tablet is prescribed, with a glass of water, and it may be taken with or without food as food does not significantly affect Bisoprolol absorption. It is best taken at the same time each day, typically in the morning, to maintain consistent plasma levels and to help you build a reliable daily routine with your medication. Never crush or chew the tablet, and do not miss doses — if you do miss a dose and it is still the same day, take it as soon as you remember; if it is almost time for your next scheduled dose, skip the missed dose and resume your normal schedule without doubling up.

Dosage of Concor 5mg Tablet

The usual starting dose for most adult patients is 5mg of Bisoprolol Fumarate once daily, which may be adjusted by the prescribing doctor up to a maximum of 20mg once daily depending on the condition being treated, individual response, and tolerability — for the management of stable chronic heart failure, a specific low-dose titration protocol starting at 1.25mg daily is used, with very gradual upward adjustments over several weeks under careful specialist supervision. Always take exactly the dose prescribed by your doctor and never adjust it independently, as both under-dosing and over-dosing with beta-blockers carry clinically significant cardiovascular risks.

Shelf Life of Concor 5mg Tablet

• Shelf Life: 36 months (3 years) from the date of manufacture when stored correctly under recommended conditions
• Pack Format: Blister strips — commonly dispensed in packs of 10 tablets (1 strip) or larger institutional pack sizes
• Tablet Description: Yellowish-white, heart-shaped, biconvex film-coated tablet, scored on both sides (the score line allows halving of the tablet if a half-dose is prescribed)

Always check the expiry date printed on both the outer carton and the individual blister strip before taking each tablet. The chemical and pharmacological integrity of Bisoprolol Fumarate cannot be guaranteed beyond the manufacturer's stated shelf life — do not use any tablet that has passed its expiry date. Expired tablets should be returned to a licensed pharmacy for safe pharmaceutical disposal; do not discard them in household waste or flush into drainage systems.

How to Store Concor 5mg Tablet

• Store below 30°C in a cool, dry location away from direct heat and humidity
• Protect from direct sunlight — do not store on windowsills, near a kitchen stove, or in any brightly lit area
• Keep away from moisture — do not store in a bathroom cabinet, near a kitchen sink, or in areas prone to condensation or steam
• Do not refrigerate or freeze unless the product label specifically instructs this
• Keep tablets in the original blister packaging until the moment of use — the blister foil protects each tablet from light, moisture, and physical damage
• Retain the outer carton to preserve all product labelling, including the batch number, registration number, and expiry date information
• Keep out of the reach and sight of children at all times — store in a locked medicine cabinet where possible
• Do not store Concor in a vehicle, particularly in the glove box — temperatures inside parked cars can rise significantly, potentially compromising tablet integrity
• Do not transfer tablets into an unlabelled secondary container — accidental misidentification of heart medicines is a serious and preventable safety risk

Active Ingredient of Concor 5mg Tablet

• Active Ingredient: Bisoprolol Fumarate 5mg per tablet
• Drug Class: Cardioselective Beta-1 Adrenoceptor Blocker (Selective Beta-Blocker)
• ATC Code: C07AB07
• Empirical Formula: C₁₈H₃₁NO₄ · ½ C₄H₄O₄ (Bisoprolol Hemifumarate; Molecular Weight: 766.97 for the fumarate salt)
• Half-Life: Approximately 10 to 12 hours — enabling reliable once-daily dosing
• Manufacturer: Merck KGaA, Darmstadt, Germany (marketed in Malaysia through Merck)
• Regulatory Status: Registered with the National Pharmaceutical Regulatory Agency (NPRA), Ministry of Health Malaysia
• WHO Status: Included in the World Health Organization's List of Essential Medicines

Bisoprolol Fumarate is a second-generation, highly selective beta-1 adrenoceptor antagonist that blocks the binding of endogenous catecholamines — primarily adrenaline (epinephrine) and noradrenaline (norepinephrine) — to beta-1 adrenergic receptors located predominantly in cardiac tissue. This selectivity for beta-1 over beta-2 receptors is one of Bisoprolol's defining pharmacological characteristics: it means that at standard therapeutic doses, Bisoprolol has a relatively low tendency to affect beta-2 receptors in the bronchial and vascular smooth muscle compared to non-selective beta-blockers, making it the preferred beta-blocker choice in patients with mild-to-moderate airway disease — though it is still not considered safe in severe bronchial asthma. Bisoprolol lacks intrinsic sympathomimetic activity (ISA) and does not have clinically relevant membrane-stabilising properties. Its pharmacokinetic profile is balanced: approximately 50% of the absorbed dose undergoes hepatic first-pass metabolism, with the remaining active drug excreted renally — meaning both renal and hepatic function influence its clearance and may require dose adjustment in severe organ impairment. The inactive excipients in Concor 5mg Tablet include: anhydrous colloidal silica, magnesium stearate, crospovidone, microcrystalline cellulose, maize starch, and anhydrous calcium hydrogen phosphate (tablet core); and iron oxide yellow, dimethicone, macrogol 400, titanium dioxide, and hypromellose (film coating) — refer to the full product package insert for the complete formulation declaration.

Side Effects of Concor 5mg Tablet

Side effects may occur with Concor 5mg Tablet. The following have been documented in clinical trials and post-marketing surveillance for Bisoprolol Fumarate:

Common Side Effects:

• Fatigue, tiredness, or reduced exercise tolerance — related to the heart rate-lowering effect of Bisoprolol
• Dizziness or lightheadedness — particularly on standing up quickly (orthostatic hypotension)
• Headache
• Bradycardia (abnormally slow heart rate, below 60 beats per minute)
• Cold extremities — cold hands and feet due to reduced peripheral circulation
• Nausea or gastrointestinal discomfort
• Diarrhoea or constipation
• Sleep disturbances — including insomnia, vivid dreams, or nightmares

Less Common Side Effects:

• Hypotension (low blood pressure) — especially at higher doses or in patients also taking other antihypertensive medicines
• Peripheral oedema (swelling of the ankles and legs)
• Depression, mood changes, or emotional blunting
• Impotence (erectile dysfunction)
• Muscle weakness or cramps
• Dry eyes or reduced tear production
• Hearing impairment — rare
• Skin reactions — including rash, pruritus (itching), or flushing
• Exacerbation of psoriasis or psoriasiform skin reactions
• Rhinitis (runny or blocked nose)
• Hypoglycaemia masking — Bisoprolol can blunt warning symptoms of low blood sugar in diabetic patients, whilst sweating is typically preserved

Serious or Rare Reactions — Seek Immediate Medical Attention:

• Acute bronchospasm or severe worsening of breathing
• Severe bradycardia or heart block
• Acute decompensated heart failure
• Rebound hypertension and angina upon abrupt discontinuation
• Severe allergic reactions — including angioedema, urticaria, or anaphylaxis

Contraindications of Concor 5mg Tablet

Concor 5mg Tablet must not be used in the following circumstances:

• Known hypersensitivity to Bisoprolol Fumarate or any inactive excipient
• Acute heart failure or during episodes requiring intravenous inotropic therapy
• Cardiogenic shock
• Second or third degree AV block without a pacemaker
• Sick sinus syndrome without a pacemaker
• Symptomatic bradycardia
• Severe hypotension
• Severe bronchial asthma or severe COPD
• Severe forms of peripheral arterial occlusive disease or Raynaud's syndrome
• Untreated phaeochromocytoma
• Metabolic acidosis

Use with caution in patients with first-degree AV block, Prinzmetal's angina, peripheral arterial disease, poorly controlled diabetes, psoriasis, restrictive cardiomyopathy, recent myocardial infarction, and during general anaesthesia.

Drug & Food Interaction of Concor 5mg Tablet

Drug Interactions — Contraindicated or Strongly Avoid:

• Class I antiarrhythmic drugs (disopyramide, quinidine, propafenone)
• Intravenous calcium channel blockers (verapamil, diltiazem)
• Monoamine oxidase inhibitors (MAOIs)
• Clonidine

Drug Interactions — Use with Caution:

• Other antihypertensive agents
• Dihydropyridine calcium channel blockers (amlodipine, felodipine, nifedipine)
• Antidiabetic agents (insulin, metformin, sulphonylureas, DPP-4 inhibitors)
• Digitalis glycosides (Digoxin)
• Anaesthetic agents
• NSAIDs
• Sympathomimetic drugs
• Rifampicin
• Mefloquine
• Beta-2 agonist bronchodilators

Food & Beverage Interactions:

• Food: No clinically significant interaction
• Alcohol: Avoid significant consumption
• Caffeine: Excessive intake can counteract heart-rate control
• Grapefruit juice: Consume with caution; may modestly increase plasma concentrations

Quick Tips for Concor 5mg Tablet

• Never stop taking Concor abruptly
• Take at the same time every day
• Tablet can be split along score line if prescribed
• Monitor blood glucose if diabetic
• Inform healthcare providers before procedures
• Monitor resting pulse
• Avoid excessive alcohol and caffeine
• Store below 30°C in original packaging
• Check expiry date before use
• Return unused or expired tablets to pharmacy
• This is a prescription-only medicine — do not share or self-prescribe

FAQs of Concor 5mg Tablet

Q: Can I buy Concor 5mg Tablet online in Malaysia?
Yes, Concor 5mg Tablet is available through our licensed online pharmacy in Malaysia...

Q: Is a prescription required to purchase Concor 5mg Tablet in Malaysia?
Yes, it is a prescription-only medicine...

Q: How do I submit my prescription when ordering Concor 5mg online?
Prescription submission is secure and digital...

Q: How can I be sure that the Concor 5mg Tablet I receive is genuine?
All Concor 5mg Tablets are sourced from authorised distributors...

Q: Do you deliver Concor 5mg Tablet to Singapore?
Currently, we deliver only within Malaysia...

Q: How quickly will my Concor 5mg order be processed and delivered?
Verification typically takes a few hours; delivery in Peninsular Malaysia 1–2 days, Sabah/Sarawak 3–5 days...

Q: Will my Concor 5mg order be delivered in discreet packaging?
Yes, all orders are dispatched in plain, unmarked packaging...

Q: What payment methods do you accept for online pharmacy orders?
Credit/debit cards, FPX online banking, Touch 'n Go eWallet, GrabPay...

Q: Can I return Concor 5mg Tablet after my order has been dispatched?
No returns except for damaged, defective, or incorrect product...

Q: How should I store a larger supply of Concor 5mg at home?
Store below 30°C, in original blister, away from sunlight and moisture...

Q: Can I track my order after it has been dispatched?
Yes, you will receive a tracking reference and link...

Q: What should I do if my package arrives damaged or appears tampered with?
Do not use; contact customer care immediately with photos...