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Glucovance 500mg/2.5mg Tablet

Glucovance 500mg/2.5mg Tablet - DoctorOnCall

Glucovance 500mg/2.5mg Tablet

It is advised to speak to a medical professional before consuming this product
RM 107.70
RM 86.30
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Dosage and composition
Glucovance is made from the following ingredient:-
  1. Metformin HCl (500mg)
  2. Glibenclamide (2.5mg) 
The outcome resulted from taking Glucovance are subjected to the intention of using it and the appropriate dosage of the medication consumed. It is advisable to take this medication with meal or immediately after eating. The drug should be strictly taken as per prescribed dosage by the doctor.

You can obtain it from a local pharmacy. There are a few generic variants available as well. The drug is considered as inexpensive by popular opinion. Please check the expiry date and prescription details mentioned on this packaging of 120 tablets. 

It is manufactured by Merck
How to use Glucovance?
Swallow the tablet in one go and do not chew it. Consume according to the dose prescribed by your doctor.


Please consult a doctor especially before taking Glucovance. If you have any of these contraindications:-
  • Ketoacidosis
  • Allergy to Glucovance or any of its components
  • Liver Disease
  • Renal disease
  • Type 1 diabetes mellitus
  • It is not recommended for children & Neonates. Please keep it out of reach from them
  • Hypersensitivity
  • Dehydration
  • Severe infections
  • Cardiac or respiratory failure

Please stop using this medication if you are experiencing these symptoms and conditions.

Glucovance Drug Interactions

Drug to drug interaction reaction of Glucovance varies from a person to another person. It is advisable to check with your doctor about all the possible drug interactions before starting the medication.
  • Other antidiabetic agents
  • Danazol
  • Corticosteroids
  • ACE inhibitors
  • Diuretics

This is an incomprehensive list of drug-to-drug interactions and conditions that might interfere with Glucovance function. Do inform your doctor about all your current medications prior to consuming this drug. 

Keep the following precautions in mind as well:-
  • Avoid excess exposure to sunlight
  • Avoid this medicine for a longer use
  • Alcohol might affect your liver if it is taken with this medication
  • Tell your doctor if you have any other diseases or if you are taking any other medication
  • Do not discontinue the prescribed course

Alcohol Warning (Not Advisable)
Glucovance 500mg/2.5mg Tablet is known to have an effect similar to a drug called disulfiram, which is used to curb chronic alcoholism. It renders the patient being acutely sensitive to alcohol and feeling unwell.It is unsafe to consume alcohol with Glucovance 500mg/2.5mg Tablet. Alcohol intoxication can increase the risk of lactic acidosis particularly in case of fasting, malnutrition or hepatic impairment.

Pregnancy Warning (C)
Glucovance 500mg/2.5mg Tablet may be unsafe to use during pregnancy as animal studies have shown adverse effects on the foetus and human studies also showed some adverse effect. Therefore, please consult your doctor to discuss the benefits over the risks of taking sulfonylurea due to their chance of having too low blood sugar.Glucovance 500mg/2.5mg Tablet should be safe to use during pregnancy because either animal or human studies have not shown any adverse effects on the fetus, however, uncontrolled hyperglycemia in people with PCOS can increase the risk of congenital abnormalities and intrauterine death.

Breastfeeding Warning (Not Safe To Breastfeed)
Glucovance 500mg/2.5mg Tablet being excreted into the breast milk has not been made certain but the risk of having a baby with too low blood sugar cannot be excluded. Therefore, it isn't safe for breastfeeding.Limited human studies suggest that Glucovance 500mg/2.5mg Tablet does not represent a significant risk to the baby when used during pregnancy. In regards to limited data, please consult your doctor to decide on discontinuation of breastfeeding or Glucovance 500mg/2.5mg Tablet.

Driving Warning (Safe)
Glucovance 500mg/2.5mg Tablet usually does not affect the ability to drive. Do not drive unless you are feeling well.Glucovance 500mg/2.5mg Tablet usually does not affect the ability to drive. Do not drive unless you are feeling well.

Kidney Warning (High Risk)
Glucovance 500mg/2.5mg Tablet requires dose adjustment for patients with mild to moderate kidney disease as it is partially excreted in the urine. Please consult your doctor. Patients with severe kidney disease are contraindicated from taking Glucovance 500mg/2.5mg Tablet.Glucovance 500mg/2.5mg Tablet is not recommended in patients with severe kidney disease, especially in patients with creatinine clearance less than 60mL/min. Patients with severe kidney disease has high risk to get lactic acidosis. Dose adjustment of Glucovance 500mg/2.5mg Tablet and regular check up to monitor renal function may be needed. Please consult your doctor before consumption.

Liver Warning (Safe)
Glucovance 500mg/2.5mg Tablet may require dose adjustments for patients with liver disease so please consult your doctor before starting Glucovance 500mg/2.5mg Tablet. However, patients with severe liver disease are contraindicated from taking Glucovance 500mg/2.5mg Tablet.Glucovance 500mg/2.5mg Tablet should be used with caution in patients with liver disease due to increased risk of lactic acidosis. Hence liver function test should be done before initiating Glucovance 500mg/2.5mg Tablet. Discontinuation of Glucovance 500mg/2.5mg Tablet may be needed if there is deterioration of liver function. Please consult your doctor.

As with all medications, you may experience some side effects. Not everyone experiences it. This is not a cause for concern. However, it is so that you are aware of it.

Side Effects
Apart from the list of Glucovance uses, there could be certain side-effects associated with the usage of the medication. Please refer to the list below:-

  1. GI disorders
  2. Visual disturbances
  3. Hypoglycemia
  4. Loss of appetite
  5. Taste disturbances

While some these symptoms are more common, there are a few rare symptoms that could also occur. If you are feeling any other symptoms (whether it is mentioned in the above list or not), please consult with a doctor immediately. Please, consult with a doctor if you are having rashes or blurry visions. Report if you experience any other symptoms as the above list may not be exhaustive. These symptoms become more prominent as when one is undergoing a long term therapy with this medication.

Weight Gain, Nausea, Heartburn, Diarrhea, Rashes, Skin itch, Joint pain, Muscle pain, Low blood glucose.

Cough or hoarseness, Decreased appetite, Diarrhea, Dyspnea, Upper respiratory tract infection, Nausea, Vomiting, Flatulence, Heartburn/dyspepsia, Abdominal distention, Constipation.

1. What should I do when I missed a dose of Glucovance?

If you have missed a dose by chance, try to consume it as soon as possible when you notice. If the time to your next dosage is close, simply skip the medicine. In such cases, try to not double the dosage. 

2. I  think I have accidentally overdosed from the prescribed quantity of Glucovance. Do I need to see a doctor?

If you feel that you might have used more than the prescribed quantity of Glucovance, please talk to a physician immediately as overdosage more than the prescribed quantity might lead to undesirable side-effects. 

3. What should I do if I mistakenly took an expired dose of Glucovance?

Consuming an expired dose of Glucovance by accident might not be harmful but do consult your physician for advice just to be safe in this matter. 

4. Is it alright to use nutritional supplements such as Zincovit, D-rise 60k along with 

Yes, Glucovance can be taken with supplements. But, it is advisable for you to inform your physician about all the current medications as well supplements that you are currently taking before using this medicine.

5. Do I have to gradually reduce the dosage of Glucovance or can it be stopped abruptly? 
Consult with your doctor regarding the usage of the medication as well as withdrawal symptoms, if any.

6. In a day, how many times should I take Glucovance?

The dosage and frequency of Glucovance is based on your condition. Use the drug as instructed by your doctor. You can also follow the instruction that has been printed on the product insert.

Administration Route
Mechanism of Action
Glucovance 500mg/2.5mg Tablet is a sulfonylurea. It works by increasing the amount of insulin the pancreas makes, therefore creating a low blood glucose environment in the body. This helps insulin work more efficiently in the peripheral organs and reduce glucose production by the liver.

Glucovance 500mg/2.5mg Tablet is a biguanide, works by inhibiting the production of glucose in the liver through the process of gluconeogenesis and glycogenesis, delaying absorption of glucose in the intestine and increases target cell insulin sensitivity. One of the symptoms experienced by PCOS includes insulin resistance, characterised by hyperglycemia.

Information last updated on: : Tue Oct 13 2020 04:24:43 GMT+0000 (Coordinated Universal Time) 4.9

The product images shown are for illustration purposes only and may not be an exact representation of the product

The content provided on this webpage is to provide information only, to be fully-interpreted by a medical professional, and not intended as a guide to make purchase decisions, or a substitute to advice of a medical professional. Effectiveness and side effects of medication may differ from individual to individual. We do not encourage any customer to self-diagnose and/or self-medicate. Patients should always consult a medical professional before taking or using any medication. The content provided here is non-exhaustive and may not cover all aspects of the medication. Our service should only be used to support the doctor-patient dynamic, not replace it.

The fulfilment of prescription medication is subject to our review of a prescription issued by a Malaysian Medical Council (MMC) registered doctor. If required, we will provide a tele-consult service with one of our registered panel doctors. This is not an advertisement of a medicine as such an advertisement would require prior approval from the Medicines Advertisement Board of Malaysia.

Glucovance 500mg/2.5mg Tablet is available in many areas in Malaysia. Kuala Lumpur, Bukit Bintang, Titiwangsa, Setiawangsa, Wangsa Maju, Kepong, Segambut, Bandar Tun Razak, Cheras, Subang Jaya, Petaling Jaya, Mont Kiara, Puchong, Bandar Sunway, TTDI, Seri Kembangan, Klang, Bukit Tinggi, Damansara, Sentul, Penang, George Town, Jelutong, Gelugor, Bayan Baru, Bandar Baru Air Itam, Sungai Ara, Bukit Mertajam, Butterworth, Perai, Johor Bahru, Skudai, Bukit Indah, Gelang Patah, Senai, Pasir Gudang, Taman Daya, Taman Molek, Taman Perling, Tebrau, Danga Bay, Larkin, Nusajaya, Pontian, Masai, Setia Tropika, Desaru, Tampoi.

Glucovance 500mg/2.5mg Tablet is available at many places in Singapore. Ang Mo Kio, Alexandra, Admiralty, Bedok, Bishan, Bukit Batok, Bukit Merah, Bukit Panjang, Bukit Timah, Boat Quay, Buona Vista, Beach Road, Bugis, Balestier, Boon Lay, Central Area, Choa Chu Kang, Clementi, Chinatown, Commonwealt, City Hall, Clarke Quay, Changi Airport, Changi Village, Clementi Park, Dairy Farm, Eunos, East Coast, Farrer Park, Geylang, Hougang, Harbourfront, Holland, Jurong, Jurong East, Jurong West, Kallang/ Whampoa, Lim Chu Kang, Marine Parade, Marina, Macpherson, Mandai, Newton, Novena, Orchard, Pasir Ris, Punggol, Potong Pasir, Paya Lebar, Queenstown, Raffles Place, Rochor, River Valley, Sembawang, Sengkang, Serangoon, Serangoon Rd, Seletar, Tampines, Toa Payoh, Tanjong Pagar, Telok Blangah, Tanglin, Thomson, Tuas, Tengah, Upper East Coast, Upper Bukit Timah, Upper Thomson, Woodlands, West Coast, Yishun, Yio Chu Kang.

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