Adapalene

Information About Adapalene

Uses of Adapalene

Adapalene is commonly used to treat acne.

How Adapalene Works

Adapalene is a retinoid-like compound which has anti-inflammatory action. Adapalene works by normalising the differentiation of follicular epithelial cells resulting in decreased acne. It binds to the specific retinoic acid nuclear formation.

Side Effects of Adapalene

Stinging and burning sensation, Skin discoloration, Sunburn, Skin irritation, Scaling and erythema, Pruritus, Rash, Eczema, Acne flare, Dermatitis

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Adapalene Related Warnings

Alcohol Not Advisable

It is unsafe to apply alcohol with Adapalene. Using Adapalene with alcohol may have additive irritant effects. You may experience skin irritation, stinging and burning sensation and sunburn.

Pregnancy Not Safe

Adapalene may be unsafe to use during pregnancy. Animal studies have shown negative effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.

Lactation Safe If Prescribed

Adapalene is probably safe to use during lactation, however, avoid application to the chest to prevent contact exposure of the infant. No human data suggests that Adapalene does not represent a significant risk to the baby.

Driving Generally Safe

Adapalene usually does not affect the ability to drive. Do not drive unless you are feeling well.

Kidney Safe If Prescribed

Adapalene can be used in patients with kidney disease since its absorption is minimal.

Liver Use With Care

Adapalene should be used with caution in patients with liver disease because it was excreted via bile. Dose adjustment may be needed. Please consult your doctor.