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Alfacalcidol

Information About Alfacalcidol

Uses of Alfacalcidol

Alfacalcidol is commonly used to treat hypocalcaemia, hypoparathyroidism, hypophophataemia, renal osteodystrophy and rickets/osteomalacia

How Alfacalcidol Works

Alfacalcidol is a precursor to calcitriol. It undergoes 25-hydroxylation in the liver to become the active calcitriol (1, 25-dihydroxyvitamin D3) which enables calcium absorption from the intestine and renal as well as from bone resorption.

Side Effects of Alfacalcidol

No appetite, Nausea, Vomiting, Increase urination, Sweating, Headache, Thirst, Skin rash, Vertigo

Information Updated on : Mon Dec 11 2023 14:41:16 GMT+0800 (Malaysia Time)

Alfacalcidol Related Warnings

Alcohol Safe

Consumption of alcohol with Alfacalcidol is thought to be safe and does not affect the absorption of Alfacalcidol based on the clinical data.

Pregnancy Not Safe

Animal studies have shown reproductive toxicity in higher dose while there is only limited data regarding the safety profile of Alfacalcidol during human pregnancy. It is therefore should be avoided to be used during pregnancy or use with caution by doctor's advice.

Lactation Limited Data

It is not fully known how much the active calcitrol will be in the breastmilk. The presence of this active metabolites may disturb the normal calcium metabolism of an infant. Hence, it is advisable to closely monitor the infant's health following the mother's intake of Alfacalcidol.

Driving Generally Safe

Generally, consumption of Alfacalcidol does not affect concentration or the ability to drive. If side effects such as headache and vertigo develop, it is not recommended for the user to drive afterwards.

Kidney Use With Care

Alfacalcidol is regularly used in patients with renal impairment. Caution should be taken to avoid hyperphosphataemia either by taking together with phosphate binders or monitoring closely level of phosphate in the blood.

Liver Safe If Prescribed

Alfacalcidol is noted to be safe and may only cause slight increase in liver enzymes level in people with hepatic impairment.

Frequently Asked Questions on Alfacalcidol

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