Allopurinol

Information About Allopurinol

Uses of Allopurinol

Allopurinol is commonly used to treat gout and tumour lysis syndrome complication during the treatment of cancer

How Allopurinol Works

Allopurinol is a xanthine oxidase inhibitor which prevents the production of uric acid.

Side Effects of Allopurinol

Rashes (flat/small raised lesions), Fever and Chills, Joint Pain, Joint Stiffness, Joint Swelling, Nausea, Vomiting, Headache, Dizziness, Taste Changes, Unexplained Nosebleeds, High Blood Pressure

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Allopurinol Related Warnings

Alcohol Not Advisable

It is not advisable to take alcohol with allopurinol as it would worsen any dizziness, blurred vision, and drowsiness.

Pregnancy Not Safe

Allopurinol may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.

Lactation Limited Data

Allopurinol is excreted in the breast milk, along with its active metabolite oxipurinol. However, no data shows any effect of allopurinol and oxipurinol in the breast milk on the baby. Ultimately, it is not recommended as of now.

Driving Not advisable

Do not drive unless you are feeling well. Allopurinol may cause side effects such as sleepiness, vertigo or loss of balance, all of which could affect the ability to concentrate and drive.

Kidney Use With Care

Allopurinol should be used with caution in patients with severe kidney disease, especially if used with diuretics. Dose adjustment of Allopurinol may be needed. Please consult your doctor.

Liver Use With Care

Patients with liver disease should use Allopurinol with caution. Dose adjustment of Allopurinol may be needed. Please consult your doctor.