Canagliflozin

Information About Canagliflozin

Uses of Canagliflozin

Canagliflozin is commonly used in the treatment of type 2 diabetes mellitus

How Canagliflozin Works

Canagliflozin acts on sodium-glucose co-transporter 2 (SGLT-2) in the proximal convoluted tubule which filtered glucose reabsorption. It inhibits the SGLT-2 thus reduces the reabsorption of glucose and increases the excretion of glucose in the urine.

Side Effects of Canagliflozin

Dry mouth, Hypovolemia, Urinary tract infection, Angioedema, Rash, Decrease bone mineral density

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Canagliflozin Related Warnings

Alcohol Not Advisable

Alcohol may affect blood sugar levels in a diabetic patient. Therefore it is not advised to drink alcohol while taking this medication.

Pregnancy Not Safe - High Risk

Canagliflozin should not be used in pregnant women. It should be discontinued if prescribed to a pregnant lady prior to pregnancy.

Lactation Not Advisable

Studies in animals have shown that Canagliflozin may be excreted in breastmilk and may carry a potential risk to newborns or infants. This medication should not be used in breastfeeding mothers.

Driving Generally Safe

Only drive if you are feeling well. Canagliflozin is less likely to impair your concentration, however, it may cause hypoglycemia when used with insulin or sulfonylureas. It also can cause hypovolemia which may present as hypotension.

Kidney Use With Care

Canagliflozin's efficacy is dependant on renal function. It is not suitable for a patient with severe renal impairment. Dose adjustment also may be needed depending on the renal function.

Liver Use With Care

No adjustment needed in a patient with mild or moderate liver impairment. However, it is not recommended to be used in patients with severe renal impairment.