Celecoxib

Information About Celecoxib

Uses of Celecoxib

Celecoxib is commonly used in the treatment of ankylosing spondylitis, osteoarthritis, severe acute pain and pain during menstruation.

How Celecoxib Works

Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor. Celecoxib works by inhibiting the synthesis of prostaglandin

Side Effects of Celecoxib

Hypertension, Upper respiratory tract infections, Cough. Myocardial infarction, Hypersensitivity, Insomnia, Headache, Dizziness, Nausea, Vomiting, Abdominal pain, Irritable bowel syndrome, GERD, Oedema, Skin rashes or pruritus

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Celecoxib Related Warnings

Alcohol Not Advisable

Celecoxib should not be used with alcohol. Alcohol intake is one of the risk factors for upper and lower gastrointestinal complications such as perforations, ulcers or bleedings. Consuming celecoxib with alcohol may increase the likelihood of developing the complications.

Pregnancy Not Safe

Celecoxib must be used with care during pregnancy. Animal reproduction studies demonstrate adverse effects on the fetus, and there are no adequate studies in pregnant women before 30 weeks of gestation. In women after 30 weeks of gestation, there is evidence of adverse effects on the fetal renal system and premature closure of the ductus arteriosus. This medication should only be used after the benefits and risks have been weighed properly. Please consult your doctor before using it.

Lactation Not Advisable

Celecoxib is shown to be excreted at concentration similar to that in the plasma in the milk of rats. Although it is said that there is very little excretion of celecoxib into human breast milk, it is not advisable for women to breastfeed while consuming Celecoxib.

Driving Generally Safe

Celecoxib usually does not affect the ability to drive. Do not drive unless you are feeling well.

Kidney Use With Care

Celecoxib should be used with caution in patients with kidney impairment. Dose adjustment of celecoxib is needed. However, it is contraindicated if patients have severe kidney impairment. Please consult your doctor before use.

Liver Use With Care

Celecoxib should be used with caution in patients with mild or moderate liver disorder. Dose adjustment of celecoxib is needed. However, it is contraindicated if patients have severe liver impairment Please consult your doctor.