Chlorambucil

Information About Chlorambucil

Uses of Chlorambucil

Chlorambucil is commonly used to treat hodgkin's disease, non-hodgkin's lymphoma, chronic lymphocytic leukaemia, waldenstrom macroglobulinaemia

How Chlorambucil Works

Chlorambucil works by interfering with DNA replication and RNA transcription by alkylation and cross-linking of the cellular DNA strands. This causes the disruption of nucleic acid function.

Side Effects of Chlorambucil

Infertility, Numbness, Nausea, Vomiting, Loss of appetite, Rash, Jaundice, Seizures, Oral ulcer, Abdominal pain

Authorship

Written By

Dr Sri Viknarajan

MD (Universiti Hasanuddin, Indonesia)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Chlorambucil Related Warnings

Alcohol Safe

There is no contraindication on the consumption of alcohol with Chlorambucil suggested by any previous clinical data.

Pregnancy Not Safe

Chlorambucil is contraindicated in pregnancy due to its potential reproductive side effects and in women of child-bearing age, effective contraception is advisable.

Lactation Not Advisable

It is not known whether Chlorambucil will be excreted into human breastmilk or not and it is advisable not to breastfeed the infant during treatment period due to its potential adverse effects.

Driving Generally Safe

It is not known whether Chlorambucil will affect the ability to drive or not. It is advisable not to drive if the patient experience side effects which can cause impairment in the ability to drive.

Kidney Use With Care

Dosage adjustment is not needed when Chlorambucil is used in patients with renal impairment. However, close monitoring is advisable.

Liver Use With Care

Dosage adjustment and close monitoring are advisable for people with hepatic impairment.