Clozapine

Information About Clozapine

Uses of Clozapine

Clozapine is commonly used to treat mania, schizophrenia, psychosis in parkinson disease and suicidal behaviour in schizophrenia

How Clozapine Works

Clozapine works by inhibiting the dopamine D2 receptor and serotonin type 2A receptor

Side Effects of Clozapine

Low blood pressure, Blackout, Seizure, Visual problem, Drooling of saliva, Urinary retention, Fast pulse, Dizziness, Insomnia, Headache

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Clozapine Related Warnings

Alcohol Not Advisable

Clozapine and alcohol consumption may worsen the effects on the central nervous system as their adverse reactions may be compounded.

Pregnancy Maybe Safe

Animal reproductive studies did not suggest any harm on Clozapine use but reports from human studies especially on the use of Clozapine on the third trimester suggest some risk to the neonates. Careful monitoring by specialists is advisable.

Lactation Not Advisable

Cilostazol has been found in breastmilk according to animal studies and due to its potential serious side effects on the infant, it is not advisable to be used during breastfeeding.

Driving Not advisable

It is not advisable to drive when taking Clozapine due to its potential side effects such as headache and dizziness which can affect the ability to drive and concentrate.

Kidney High Risk

Dosage adjustment is needed in patients with mild to moderate renal impairment and is contraindicated to be used in patients with severe renal impairment.

Liver Use With Care

Dosage adjustment is needed in patient with mild to moderate hepatic impairment while it is contraindicated to be used in severe hepatic impaired patients.