Dexlansoprazole

Information About Dexlansoprazole

Uses of Dexlansoprazole

Dexlansoprazole is commonly used in the treatment of gastroesophageal reflux disease, intestinal ulcer, peptic ulcer disease and stomach ulcer, and to treat stomach acidity, acid reflux and heartburn.

How Dexlansoprazole Works

Dexlansoprazole is a proton pump inhibitor. It is an antacid which works by blocking (H+/K+)-ATPase enzyme in gastric parietal cells which is the final step of acid secretion. It thus reduce the acid production in the stomach.

Side Effects of Dexlansoprazole

Acute interstitial nephritis, Diarrhea, Osteoporosis-related fracture, Cutaneous/ Systemic Lupus Erythematous, Vit B12 deficiency, Headache/ Dizziness, Altered taste, Nausea, Abdominal pain, Flatulence, Shortness of breath

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Dexlansoprazole Related Warnings

Alcohol Not Advisable

Taking Dexlansoprazole with alcohol may have additive effects in worsening the side effects. You may experience headache, dizziness, lightheadedness, nausea and abdominal pain.

Pregnancy Maybe Safe

Dexlansoprazole is not recommended to use during pregnancy. Both studies, either animal or human, cannot show the potential risk to the pregnancy or teratogenic risk to the fetus. The confirmation of Dexlansoprazole cannot be sure, thus, it may be unsafe to use during pregnancy. Please consult your doctor.

Lactation Limited Data

Dexlansoprazole is probably safe to use during lactation. No observed data in both animal and human studies suggests the harmful risk of Dexlansoprazole to the baby. However, Dexlansoprazole is a R-isomer of lansoprazole, a drug that is excreted in human breast milk, so the benefits from use in breastfeeding mothers should be considered in both mothers and infants despite the risks. Please consult your doctor.

Driving Use With Care

Do not drive unless you are feeling well. Dexlansoprazole may cause side effects such as dizziness, headaches or nausea, all of which could affect your ability to concentrate and drive.

Kidney Use With Care

Dexlansoprazole should be used with caution in patients with kidney disease. 51% of Dexlansoprazole's metabolites are excreted in the urine. Renal impairment will affect the excretion process and lead to the accumulation of the drug in the body. Dose adjustment of Dexlansoprazole may be needed. Please consult your doctor.

Liver Limited Data

Patients with liver disease should use Dexlansoprazole with caution and use of Dexlansoprazole is not recommended in patients with severe liver disease (Child-Pugh Class C). Dexlansoprazole is majorly metabolised by the enzyme in the liver. CYP2C19 enzyme helps in the hydroxylation of Dexlansoprazole and CYP3A4 enzyme do the oxidation of Dexlansoprazole. In absence of these enzymes in patients with liver disease will increase Dexlansoprazole concentration in the blood plasma. Dose adjustment of Dexlansoprazole may be needed. Please consult your doctor.