Diphenhydramine

Information About Diphenhydramine

Uses of Diphenhydramine

Diphenhydramine is commonly used to treat allergic skin conditions, insomnia, morning sickness, motion sickness, nasal allergy symptoms, vertigo and used as an appetite stimulant.

How Diphenhydramine Works

Diphenhydramine is an antihistamine with anticholinergic and sedative effects. It works by competitively inhibiting histamine H1-receptor in the gastrointestinal and respiratory tract and blood vessels, thus prevents the release of histamine and other inflammatory mediators.

Side Effects of Diphenhydramine

Chest tightness, Hypotension, Palpitations' Difficulty in micturition, Confusion, Dizziness, Drowsiness, Mood imbalance, Sleep disturbances, Restlessness, Sedation, Diarrhea/ constipation

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Diphenhydramine Related Warnings

Alcohol Not Advisable

It is unsafe to consume alcohol with Diphenhydramine.Taking Diphenhydramine with alcohol may have additive CNS depressants.

Pregnancy Maybe Safe

Diphenhydramine may be unsafe to use during pregnancy. Animal studies have not shown adverse effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.

Lactation Limited Data

Diphenhydramine may be excreted in breastmilk. No human data suggests that Diphenhydramine does not represent a significant risk to the baby. Diphenhydramine is not recommended for use during lactation. Please consult your doctor.

Driving Not advisable

Do not drive unless you are feeling well. Diphenhydramine may cause side effects such as sedation, drowsiness, dizziness, headaches, and psychomotor impairment, all of which could affect your ability to concentrate and drive.

Kidney Use With Care

Diphenhydramine should be used with caution in patients with severe kidney disease. Please consult your doctor.

Liver Limited Data

Diphenhydramine should be used with caution in patients with liver disease. Dose adjustment of Diphenhydramine may be needed. Please consult your doctor.