Diphenoxylate

Information About Diphenoxylate

Uses of Diphenoxylate

Diphenoxylate is commonly used in the treatment of diarrhea

How Diphenoxylate Works

Diphenoxylate affects the smooth muscles of the intestinal tract where it causes slowing down of the intestinal motility and reduces the excessive GI propulsion.

Side Effects of Diphenoxylate

Headache, Drowsiness, Dizziness, Restlessness, Euphoria, Depression, Numbness of the extremities, Hypersensitivity reaction, Gum swelling

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Diphenoxylate Related Warnings

Alcohol Not Advisable

It is not advisable to take alcohol with Diphenoxylate as it would potentiate effects of CNS depressants

Pregnancy Not Safe

Diphenoxylate may be unsafe to use during pregnancy. Animal studies have shown side effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable even with the risk. Please consult your doctor.

Lactation Not Advisable

Diphenoxylate is shown to be excreted in breast milk. It is not advisable for women to breastfeed while consuming Diphenoxylate because of its potential adverse effects on infants.

Driving Not advisable

Do not drive unless you are feeling well. Diphenoxylate may cause side effects such as dizziness, drowsiness or numbness, all of which could affect the ability to concentrate and drive.

Kidney Safe If Prescribed

Diphenoxylate is safe to be used in patients with kidney disease and no dosage adjustment required. However, please consult your doctor.

Liver Use With Care

Diphenoxylate should be used with caution in patients with liver disease. Dose adjustment of Diphenoxylate may be needed. Please consult your doctor.