Doxazosin

Information About Doxazosin

Uses of Doxazosin

Doxazosin is commonly used in the treatment of benign prostatic hyperplasia, hypertension (high blood pressure), and raynaud's disease.

How Doxazosin Works

Doxazosin is an alpha-receptor antagonist. It blocks the receptors located at prostate tissue, and vascular beds by inhibiting completely postsynaptic É‘1 receptor at vascular beds

Side Effects of Doxazosin

Drowsiness, Dizziness, Headache, Syncope, Palpitation, Chest pain, Lethargy, Nausea, Abdominal pain, Diarrhea, Dry mouth, Orthostatic hypotension

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Doxazosin Related Warnings

Alcohol Not Advisable

It is not advisable to consume alcohol with Doxazosin. Taking Doxazosin with alcohol may have additive effects in lowering blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate.

Pregnancy Not Safe

Doxazosin may be unsafe to use during pregnancy. Animal studies have shown reducing fetal survival, however, there are limited human studies to prove the safety of Doxazosin. The benefits from use in pregnant women may be acceptable despite the risk which must need the opinion of the physician. Please consult your doctor.

Lactation Limited Data

Doxazosin may be unsafe to use during lactation. Approximately 20 times greater than the maternal plasma concentration of Doxazosin will excrete in rat milk in an animal study. However, limited human data suggests that Doxazosin does not represent a significant risk to the baby. Please consult your doctor.

Driving Not advisable

Do not drive while taking this medication unless you are feeling well. Doxazosin may cause side effects such as dizziness, headaches, nausea or tiredness, all of which could affect your ability to concentrate and drive.

Kidney Use With Care

Doxazosin should be used with caution in patients with kidney disease. Although renal impairment will not affect the pharmacokinetics of this drug, renal function need to be monitored to prevent an unwanted effects since Doxazosin is not dialyzed. Please consult your doctor before using it.

Liver Limited Data

Use of Doxazosin is not recommended in patients with liver disease. In a clinical study among people with liver impairment, Doxazosin will increase 43% of drug concentration in the blood plasma. This may lead to unwanted toxicity. Dose adjustment of Doxazosin may be needed. Please consult your doctor.