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Flecainide is commonly used in the treatment of arrhythmias.
Flecainide works by inhibiting the transmembrane influx of extracellular sodium ions which reduced the rate of depolarization of the action potential which prolongs the PR and QRS intervals.
Dizziness, Nausea, Vomiting, Visual disturbances, Headache, Tremor, Peripheral neuropathy, Syncope, Vertigo, Increased sweating, Anxiety, Pro-arrhythmic effects
It is not advisable to consume alcohol with flecainide as the alcohol may worsen the side effects of Flecainide such as dizziness.
Animal studies have shown that high doses of flecainide can cause some fetal abnormalities in New Zealand White rabbits. However, there are inadequate human studies on the usage of Flecainide in pregnancy. Some data reported that flecainide may cross the placenta and thus it should only be used if the benefits outweigh the risks to the fetus.
Flecainide is found to be excreted in human breast milk, therefore it should only be used if the benefits of treatment outweigh the benefits of breastfeeding to the infant.
Do not drive unless you are feeling well. Flecainide may cause side effects such as dizziness or visual disturbances, all of which could affect the ability to concentrate and drive.
Flecainide should be used with caution in patients with renal impairment. The maximum initial dose should be 100mg daily and it is recommended to do frequent plasma level monitoring. Some patients with underlying severe renal failure can have a very slow flecainide clearance and as a result, prolonged half-life.
Patients with liver impairment should use Flecainide with caution and must be closely monitored.
