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Information About Letrozole

Uses of Letrozole

Letrozole is commonly used to treat breast cancer, infertility, infertility due to anovulation

How Letrozole Works

Letrozole is a non-steroidal aromatase enzyme inhibitor. It significantly reduces serum oestrogen concentration by competitively bind to an enzyme, blocking the conversion of androstenedione and testosterone into oestriol and oestradiol respectively.

Side Effects of Letrozole

Increased cholesterol level, Increased/decreased appetite, Difficulty sleeping (insomnia), Depression, Dizziness, Headache, Palpitations , Hot flushes , Hypertension, Perfused sweating

Information Updated on : Fri Jul 08 2022 11:34:40 GMT+0800 (Malaysia Time)

Letrozole Related Warnings

Alcohol Safe

It is safe to consume alcohol with Letrozole as there is no known drug interactions.

Pregnancy Not Safe - High Risk

Letrozole is contraindicated in pregnancy as there are reported cases of congenital malformations such as ambiguous genitalia and labial fusion.

Lactation Not Advisable

There is no information regarding the presence of Letrozole and its metabolites in human milk. Therefore, the risk of adverse effects cannot be excluded and it is not recommended to use the medication during the nursing period.

Driving Not advisable

Letrozole may cause side effects such as dizziness, headaches, nausea or tiredness, all of which could affect your ability to concentrate and drive.

Kidney Use With Care

No dose adjustment of Letrozole is needed in mild to moderate kidney disease. There is no information regarding dose titration in severe kidney disease. Therefore, Letrozole should be used with caution in severe kidney disease. Please consult your doctor.

Liver Use With Care

Letrozole should be used with caution in patients with severe liver disease as dose adjustment of Letrozole may be needed. However, in mild to moderate liver disease, no dose adjustment is required. Please consult your doctor.

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