Meloxicam

Information About Meloxicam

Uses of Meloxicam

Meloxicam is commonly used to treat ankylosing spondylitis, osteoarthritis and rheumatoid arthritis.

How Meloxicam Works

Meloxicam is a Nonsteroidal anti-inflammatory drug (NSAID) that reversibly blocks the cyclooxygenase-1 and -2 (COX-1 and -2) enzymes, causing a reduction in synthesis of prostaglandin precursors.

Side Effects of Meloxicam

Headache, Peptic ulcers, perforation or GI bleeding, Nausea, vomiting, Diarrhea, flatulence, constipation, dyspepsia, abdominal pain, melaena, haematemesis, fluid retention, malaise, fatigue.

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Meloxicam Related Warnings

Alcohol Not Advisable

GI bleeding, ulceration or perforation has been reported with NSAIDs at any time during treatment. Consuming alchol while on Mefenamic acid are added risk factors.

Pregnancy Not Safe

NSAIDs should not be used during the first two trimesters of pregnancy unless the potential benefit to the patient outweighs the potential risk to the foetus. If so, Meloxicam is given at the lowest dose and for a short duration of treatment. Mefenamic acid is contraindicated during 3rd trimester of pregnancy due to risk of closure of the ductus arteriosus, delayed onset of labour and risk of bleeding to mother and child.

Lactation Limited Data

No human data describing the use of meloxicam for breastfeeding mothers. However, Meloxicam is not recommended for use during lactation.

Driving Generally Safe

There are no studies of Meloxicam on the ability to drive. Do not drive unless you are feeling well.

Kidney Use With Care

Meloxicam can be used in patients with mild and moderate kidney disease. No dose adjustment of Meloxicam may be needed. In severe renal failure, dose should be less than 7.5 mg per day. Please consult your doctor before usage.

Liver Limited Data

Meloxicam should be used with caution in patients with severe liver disease and dose adjustment may be needed. Please consult your doctor before usage.