Melphalan

Information About Melphalan

Uses of Melphalan

Melphalan is commonly used to treat multiple myeloma, breast cancer, ovarian carcinoma, polycythaemia vera, ovarian adenocarcinoma, neuroblastoma, melanoma and soft tissue sarcoma.

How Melphalan Works

Melphalan is an alkylating agent. Forming the metabolite carbonium ions, it cross-links DNA strands and acts on both resting and rapidly dividing tumour cells, thereby inhibiting DNA and RNA synthesis.

Side Effects of Melphalan

Bone marrow suppression, Nausea, Vomiting, Diarrhea, Stomatitis, Alopecia

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Melphalan Related Warnings

Alcohol Safe

Consuming alcohol in moderation doesn't cause disturbance to the pharmacokinetics of Melphalan. However, please consult your doctor before using it.

Pregnancy Not Safe

Melphalan may be unsafe to use during pregnancy. There is evidence of adverse effects on the fetus in human studies but the benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor before using it.

Lactation Not Advisable

Melphalan is not recommended for use during lactation.

Driving Generally Safe

Melphalan cause minimal to no side effects which could affect your ability to concentrate and drive.

Kidney Use With Care

Melphalan should be used with caution in patients with kidney disease. Dose adjustment of Melphalan may be needed. Please consult your doctor before using it.

Liver Use With Care

Melphalan should be used with caution in patients with liver disease. Dose adjustment of Melphalan may be needed. Please consult your doctor before using it.