Methotrexate

Information About Methotrexate

Uses of Methotrexate

Methotrexate is commonly used to treat blood cancer, breast cancer, head and neck cancer, lung cancer, non hodgkin lymphoma nhl, psoriasis, rheumatoid arthritis, choriocarcinoma, mycosis fungoides, crohn's disease, osteosarcoma

How Methotrexate Works

Methotrexate which is a folic acid antagonist works by inhibiting the enzymes responsible for the building blocks of DNA hence blocking the DNA synthesis.

Side Effects of Methotrexate

Mouth ulcer, Skin rash, Balding of the head, Joint pain, Anaemia, Nausea, Vomiting, Fatigue, Dizziness

Authorship

Written By

Dr Sri Viknarajan

MD (Universiti Hasanuddin, Indonesia)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Methotrexate Related Warnings

Alcohol Not Advisable

Consumption of alcohol with Methotrexate may potentiates the hepatotoxicity of the latter.

Pregnancy Not Safe - High Risk

Methotrexate is strictly contraindicated for a pregnant woman. Effective contraception is advisable in child-bearing age woman if the treatment is started.

Lactation Not Advisable

Methotrexate is present in human breastmilk and because of the potential toxicity towards the nursing infants, it is contraindicated to be used during breastfeeding.

Driving Not advisable

It is not advisable to drive when under Methotrexate treatment due to its potential side effects such as fatigue and dizziness which can affect the ability to concentrate and drive.

Kidney High Risk

Dosage adjustment is needed for patients with mild to moderate renal impairment and is contraindicated for patients with severe renal impairment.

Liver Use With Care

Dosage adjustment is needed for patients with hepatic impairment based on their bilirubin value. It is contraindicated to be used if the bilirubin value is more than 5mg/dL.