Pazopanib

Information About Pazopanib

Uses of Pazopanib

Pazopanib is commonly used to treat renal cell carcinoma and soft tissue sarcoma

How Pazopanib Works

Pazopanib is a tyrosine kinases receptor inhibitor (RTKs). RTKs involved in the blockade include receptors for vascular endothelial growth factors, platelet-derived growth factors, and stem cell factor.

Side Effects of Pazopanib

Diarrhea, Hair colour change, Skin hypopigmentation, Exfoliative rash, Increased blood pressure, Nausea, Headache, Fatigue, Loss of appetite, Vomiting, Distortion of the sense of taste, Stomatitis, Weight decreased, Elevated liver enzymes

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Pazopanib Related Warnings

Alcohol Limited Data

Certain food and medications will have interactions with concurrent use of Pazopanib but there is no specific data stating so. Please consult your doctor before using it.

Pregnancy Not Safe

Human studies have shown adverse effects on the fetus. However, the benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor before using it.

Lactation Limited Data

It is unknown whether Pazopanib is excreted into human breast milk and its potential adverse effect on the feeding baby. Please consult your doctor before using it.

Driving Generally Safe

Pazopanib cause negligible to no side effects which could affect your ability to concentrate and drive. Do not drive unless you are feeling well.

Kidney Use With Care

Pazopanib should be used with caution in patients with mild kidney disease. Dose adjustment of Pazopanib is not needed. Please consult your doctor before using it. Use of Pazopanib in patients with moderate to severe kidney disease is unknown.

Liver Limited Data

Pazopanib should be used with caution in patients with mild to moderate liver disease. Dose adjustment of Pazopanib may be needed. Please consult your doctor before using it. Use of Pazopanib is not recommended in patients with severe kidney disease.