Pethidine

Information About Pethidine

Uses of Pethidine

Pethidine is commonly used as anesthesia, and control of moderate to severe pain

How Pethidine Works

Pethidine is an opioid analgesic. It activates opioid receptors in the nervous system by mimicking endogenous opioids which reduce the release of neurotransmitters and postsynaptic neuronal activity in the spinal cord leading to the prevention of transmission of pain impulses.

Side Effects of Pethidine

Hypotension, fatigue, drowsiness, dizziness, nervousness, headache, restlessness, malaise, confusion, depression, hallucinations, tremors, muscle twitches, increased intracranial pressure, seizure, rash, urticaria, nausea, vomiting, constipation, anorexia, stomach cramps, ureteral spasms, decreased urination, pain at inj site, physical and psychological dependence.

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Pethidine Related Warnings

Alcohol Not Advisable

It is not advisable to drink alcohol with Pethidine as alcohol it can cause enhanced sedative and hypotensive effects of the medication.

Pregnancy Not Safe

Pethidine may be unsafe to use especially during early pregnancy. Animal studies have shown side effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.

Lactation Not Advisable

Pethidine is shown to be excreted in breast milk. It is not advisable for women to breastfeed while consuming Pethidine because of its potential adverse drug effects on infants.

Driving Not advisable

Do not drive unless you are feeling well. Pethidine may cause side effects such as delaying reaction time, dizziness or sleepiness, all of which could affect the ability to concentrate and drive.

Kidney Use With Care

Pethidine should be used with caution in patients with kidney impairment. Dose adjustment of Pethidine may be needed. Please consult your doctor.

Liver Use With Care

Pethidine should be used with caution in patients with chronic liver disorder. Dose adjustment of Pethidine may be needed. Please consult your doctor.