Propafenone

Information About Propafenone

Uses of Propafenone

Propafenone is commonly used to treat arrhythmias

How Propafenone Works

Propafenone works by altering the intake of fast sodium ions thus causing the prolongation of the conduction and refractoriness of the heart muscle electrical conductivity. This slows down the erratic nerve conduction.

Side Effects of Propafenone

Dizziness, Headache, Visual disturbance, Vertigo, Dry mouth, Nausea, Vomiting, Skin rash, Altered taste

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Propafenone Related Warnings

Alcohol Not Advisable

It is not advisable to consume alcohol when taking Propafenone due to the cardiac depressant side effect towards the heart rate.

Pregnancy Not Safe

There are very limited and well-controlled studies regarding the effects on human pregnancy. It is known to cross the placenta and thus Propafenone should be used when the benefits outweigh the risks.

Lactation Limited Data

Limited data suggest that Propafenone may be excreted into human breastmilk and thus it is not recommended to be used during breastfeeding unless the benefits outweigh the risks.

Driving Not advisable

It is not advisable to drive after Propafenone treatment due to its potential side effects such as dizziness and headache which can affect the ability to concentrate and drive.

Kidney Use With Care

Dosage adjustment may be needed in patients with renal impairment.

Liver Limited Data

Dosage adjustment may be needed for patient with hepatic impairment as Propafenone is extensively metabolised by the liver.