Propiverine

Information About Propiverine

Uses of Propiverine

Propiverine is commonly used to treat overactive bladder (oab) symptoms

How Propiverine Works

Propiverine inhibits detrusor muscle activity by inhibiting Ca influx and modulating intracellular Ca in urinary bladder smooth muscle cells. It also inhibits the stimulation of pelvic nerves due to anticholinergic action.

Side Effects of Propiverine

Headache, Abnormal accommodation reflex, Dry mouth, Constipation, Indigestion, Fatigue, Abdominal pain, Blurry vision, Dizziness

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Propiverine Related Warnings

Alcohol Safe

It is safe to consume alcohol with Propiverine as there is no known drug interaction.

Pregnancy Limited Data

Propiverine may be unsafe to use during pregnancy. Animal studies have shown reproductive toxicity on the fetus, however, there are limited human studies.

Lactation Not Advisable

Propiverine is not safe to use during lactation as it is found to be excreted in mammal milk.

Driving Not advisable

There is no information regarding Propiverine influence on the ability to drive. However, it may cause side effects such as dizziness and blurry vision all of which could affect your ability to concentrate and drive.

Kidney Use With Care

Dose titration is not necessary in mild to moderate kidney disease. On the other hand, Propiverine should be used with caution in patients with severe kidney disease.

Liver Use With Care

There is no need to make dose adjustment of Propiverine in mild liver disease. Nevertheless, in moderate to severe liver disease, Propiverine is contraindicated.