Rilpivirine

Information About Rilpivirine

Uses of Rilpivirine

Rilpivirine is commonly used to treat hiv infection

How Rilpivirine Works

Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) which will help to reduce the viral DNA synthesis, leading to the prevention of viral proliferation and viral death.

Side Effects of Rilpivirine

Mental disturbances, Central obesity, Hepatotoxicity, Allergic reactions, Immune reconstitution syndrome, Abdominal pain, Dry mouth, Vomiting, Increased cholesterol and triglyceride level, Decreased red blood cells/white blood cells/platelets, Decreased appetite, Drowsiness

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Rilpivirine Related Warnings

Alcohol Not Advisable

Alcohol is not recommended in the first 4 weeks of therapy and it is not advisable to be used as alcohol will further damage the liver caused by Rilpivirine.

Pregnancy Limited Data

Animal studies have not shown any reproductive toxicities but there are limited data on the use of Rilpivirine in pregnant women. Thus, it is not advisable to be used during pregnancy. Please consult your doctor.

Lactation Not Advisable

Excretion of Rilpivirine has been found in animal milk but it is unknown in human breast milk. An HIV-infected mother is not recommended to breastfeed the baby to prevent transmission and adverse effects of Rilpivirine. Please consult your doctor.

Driving Generally Safe

Rilpivirine usually does not affect the ability to drive. Do not drive unless you are feeling well.

Kidney Use With Care

Caution use has to be practised in patients with severe or end-stage kidney disease. Please consult your doctor.

Liver Use With Care

Caution use has to be practised in patients with moderate liver impairment. Rilpivirine is contraindicated in patients with severe liver impairment. Please consult your doctor.