Roflumilast

Information About Roflumilast

Uses of Roflumilast

Roflumilast is commonly used to treat chronic obstructive pulmonary disease (copd)

How Roflumilast Works

Roflumilast is a phosphodiesterase-4 inhibitor which has anti-inflammatory and anti-modulatory effects in the lungs.

Side Effects of Roflumilast

Weight loss, Anxiety, Insomnia, Abdominal pain, Nausea, Diarrhea, Decreased appetite, Back pain, Headache, Dizziness

Information Updated on : Mon Apr 22 2024 15:53:24 GMT+0800 (Malaysia Time)

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Available Medicine for Roflumilast

Daxas 500mcg Tablet

Roflumilast Related Warnings

Alcohol Not Advisable

There is no known interaction between alcohol and Roflumilast when consumed concomitantly. However, alcohol is not advisable for a patient with COPD as it will worsen the condition.

Pregnancy Not Safe

Animal studies have shown reproductive toxicities but there are limited data on the use of Roflumilast in pregnant women. Thus, it is not advisable to be used during pregnancy.

Lactation Not Advisable

Excretion of Roflumilast has been found in animal milk but it is unknown in human breast milk. Thus, it is not advisable to be used during breastfeeding as risks cannot be excluded.

Driving Generally Safe

Roflumilast usually does not affect the ability to drive. Do not drive unless you are feeling well.

Kidney Safe If Prescribed

Roflumilast is safe to be used in patients with kidney impairment.

Liver Use With Care

Dose adjustment is needed in patients with mild liver impairment. Roflumilast is contraindicated in patients with moderate to severe liver impairment.

Frequently Asked Questions on Roflumilast

FAQ

Does Roflumilast cause weight loss?

Yes, it does. However, the extent of weight loss was mostly seen in the first 4 weeks of treatment with Roflumilast and was shown to occur in patients with greater fat mass. Patients were able to regain one-half of their weight lost in 3 months after discontinuing treatment with Roflumilast.

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