Ruxolitinib

Information About Ruxolitinib

Uses of Ruxolitinib

Ruxolitinib is commonly used to treat chronic idiopathic myelofibrosis and polycythemia vera.

How Ruxolitinib Works

Ruxolitinib is a selective Janus Associated Kinase (JAK) inhibitor. This is particularly helpful in patients with myelofibrosis and polycythemia vera which are characterized by abnormal JAK activity.

Side Effects of Ruxolitinib

Decreased in red blood cells/white blood cells/platelets, Increased risk of infections, Increased cholesterol and triglycerides level, Difficulty in breathing, Gut disturbances, Liver enzyme dysfunction, Weight gain, Oedema, Muscle spasm, Headache, Dizziness, Insomnia

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Ruxolitinib Related Warnings

Alcohol Not Advisable

There is no known interaction between alcohol and Ruxolitinib when consumed concomitantly. However, it is not advisable to consume alcohol when receiving anticancer treatment.

Pregnancy Not Safe

Animal studies have shown reproductive toxicities but there are no human studies have been conducted. Thus, Ruxolitinib is contraindicated during pregnancy. Please consult your doctor.

Lactation Not Advisable

Excretion of Ruxolitinib has been found in animal milk but it is unknown in human breast milk. Thus, it is not advisable to be used during breastfeeding as the risks cannot be excluded. Please consult your doctor.

Driving Generally Safe

Ruxolitinib usually does not affect the ability to drive. Do not drive unless you are feeling well.

Kidney Use With Care

Dose adjustment is needed for patients with severe and end-stage kidney disease on dialysis. Please consult your doctor.

Liver Use With Care

Dose adjustment is needed in patients with liver impairment. Please consult your doctor.