Sirolimus

Information About Sirolimus

Uses of Sirolimus

Sirolimus is commonly used to treat lymphangiomyomatosis and used as prevention of kidney transplant rejection.

How Sirolimus Works

Sirolimus is a macrolide that is able to suppress our immune mediators, subsequently suppresses the over-activation of our immune system.

Side Effects of Sirolimus

Increased risk of infection, Hypokalaemia, Dyslipidaemia, Hypophosphataemia, Hyperglycaemia, Headache, Gut disturbances, Liver dysfunction, Skin rash, Joint pain, Proteinuria, Menstrual disorder, Oedema, Anaemia/Low platelet/Low white blood cell

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Sirolimus Related Warnings

Alcohol Not Advisable

There is no known interaction between alcohol and Sirolimus when used concomitantly. However, it is not advisable to use alcohol during the treatment of Lymphangiomyomatosis and after kidney transplant.

Pregnancy Not Safe

Animal studies have shown reproductive toxicities and there are limited data on the use of Sirolimus in pregnant women. Thus, Sirolimus is not advisable to be used during pregnancy. Please consult your doctor.

Lactation Not Advisable

Excretion of Sirolimus has been found in animal milk but it is unknown in human breast milk. To prevent the potential of adverse effect on breastfed babies, it is advisable not to use Sirolimus during breastfeeding. Please consult your doctor.

Driving Generally Safe

Sirolimus usually does not affect the ability to drive. Do not drive unless you are feeling well.

Kidney Safe If Prescribed

Sirolimus is safe to be used in patients with kidney impairment.

Liver Use With Care

Caution use and dose adjustment are needed for patients with liver impairment. Please consult your doctor.