Tramadol

Information About Tramadol

Uses of Tramadol

tramadol is commonly used as an anesthesia and in the treatment of moderate to severe pain, and opioid dependence

How Tramadol Works

Tramadol which is an opioid analgesic acts centrally by inhibiting the reuptake of norepinephrine and enhancing the serotonin release. It also binds to mu-opiate receptors in the Central Nervous System thus altering perception and response to pain stimulus.

Side Effects of Tramadol

Respiratory depression, Seizure, Dizziness, Headache, Fatigue, Weakness, Sweating, Confusion, Disturbance in coordination, Rashes

Authorship

Written By

Dr Sri Viknarajan

MD (Universiti Hasanuddin, Indonesia)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Tramadol Related Warnings

Alcohol Not Advisable

Efficacy of tramadol decreases if patient is taking alcohol and patient easily become intoxicated when taking alcohol along with it, increasing the side effects of Tramadol.

Pregnancy Not Safe

Animal studies revealed that Tramadol given at very high doses showed effects on organ development, bone tissue formation, and neonatal mortality. However, teratogenic effects were not observed. Nevertheless, limited data available on the safety of tramadol in human fetal risk. Tramadol should not be used in pregnant women.

Lactation Not Advisable

A quite significant amount of Tramadol is excreted into the breast milk, therefore, Tramadol should not be used while lactating however it is not necessary to discontinue breastfeeding after a single dose of this medication

Driving Not advisable

Do not drive unless you are feeling well. Tramadol may cause side effects such as dizziness, headches, nausea or palpitations, all of which could affect the ability to concentrate and drive.

Kidney Use With Care

Tramadol should be used with care in patients suffering from kidney diseases especially advance chronic kidney disease as its systemic elimination is reduced.

Liver Use With Care

In patients with hepatic insufficiency, the removal of tramadol is delayed, therefore it should be used cautiously.