Valganciclovir

Information About Valganciclovir

Uses of Valganciclovir

Valganciclovir is commonly used to treat cytomegaloviral retinitis in aids patients and prophylaxis of cytomegaloviral infections in immunocompromised patients.

How Valganciclovir Works

Valganciclovir is an antiviral which will be converted into ganciclovir and phosphorylated into a triphosphate form by viral enzymes. This form will incorporate into the adenosine bases of viral DNA subsequently prevent viral DNA synthesis and their activities.

Side Effects of Valganciclovir

Abdominal pain, Diarrhea, Nausea, Vomiting, Headache, Insomnia, Allergy reaction, Decreased appetite, Visual disturbances, Cough, Shortness of breath, Liver dysfunction, Muscle/Joint pain, Fever, Tiredness

Authorship

Written By

Dr Sri Viknarajan

MD (Universiti Hasanuddin, Indonesia)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Valganciclovir Related Warnings

Alcohol Safe

There is no known interaction between alcohol and Valganciclovir when used concomitantly.

Pregnancy Not Safe

Animal studies have shown reproductive toxicities caused by its active metabolite, Ganciclovir but the safety profile of Valganciclovir has not been established in pregnant women. Thus, Valganciclovir is not advisable to be used during pregnancy unless the benefits outweigh the risks. Please consult your doctor.

Lactation Not Advisable

Animal studies have shown that its active metabolite, Ganciclovir is excreted in the milk but it is not known in human milk. Thus, breastfeeding is not recommended for patients who are receiving Valganciclovir treatment.

Driving Generally Safe

There are no studies of Valganciclovir on the ability to drive. Do not drive unless you are feeling well.

Kidney Use With Care

Valganciclovir dosage has to be adjusted according to the creatinine clearance of patients with kidney impairment. It is not advisable to be used in patients with creatinine clearance less than 10ml/min and patients requiring haemodialysis. Please consult your doctor.

Liver Use With Care

The safety profile of Valganciclovir has not been established in patients with liver impairment. Thus, caution use has to be practised in such patients.