Venlafaxine

Information About Venlafaxine

Uses of Venlafaxine

Venlafaxine is commonly used to treat anxiety disorder, depression and panic disorder.

How Venlafaxine Works

It is hypothesized that Venlafaxine is a potent serotonin and noradrenaline reuptake inhibitor (SNRI) and weak dopamine reuptake inhibitor. This mechanism can potentiate the action of neurotransmitters

Side Effects of Venlafaxine

Decreased appetite, Confusional state, Libido decreased, Nervousness, Insomnia, Abnormal dreams, Sleepiness, Visual disturbance, Tinnitus, Palpitation, Increased blood pressure, Altered bowel habit, Increased blood cholesterol

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Venlafaxine Related Warnings

Alcohol Not Advisable

Venlafaxine is a CNS-active substance which should be avoided taking simultaneously with alcohol.

Pregnancy Not Safe

Animal studies have shown reproductive toxicity but there are no adequate data of potential risks on pregnant women. Thus, Venlafaxine is not advisable to be used during pregnancy unless the benefits outweigh the risks.

Lactation Not Advisable

Venlafaxine and its metabolite are found to be secreted in human milk which has been reported to cause irritability and abnormal sleep patterns in breastfed babies. Thus, the decision has to be made whether to discontinue the medication or breastfeeding based on the benefit-risk ratio. Please consult your doctor.

Driving Not advisable

Do not drive unless you are feeling well. Venlafaxine may cause side effects such as impaired judgement, thinking and motor skills, all of which could affect your ability to concentrate and drive.

Kidney Use With Care

Dose adjustment may be needed in patients with severe kidney impairment and patients requiring haemodialysis.

Liver Use With Care

Dose adjustment may be needed in patients with mild to moderate liver impairment. Caution use needs to be practised in patients with severe liver impairment as there are limited data in this group of patient.