Vitamin B1/Thiamine is usually given parenterally to prevent Wernicke-Korsakoff Syndrome.
Thiamine is an essential enzyme that form thiamine pyrophosphate when combines with ATP and involves in the carbohydrate metabolism
Warm sensation, Tingling, Pruritus and urticaria, Pain, Respiratory distress, Angioedema, Gastrointestinal bleeding, Transient vasodilation and hypotension, Vascular collapse, Anaphylactic shock
There is no known harmful interaction between Vitamin B1/Thiamine and alcohol and in fact, alcoholic patients were given vitamin B1 intravenously because they may have reduced absorption of vitamin B1.
Vitamin B1/Thiamine may be safe to use during pregnancy. Controlled studies in women fail to demonstrate a risk to the foetus in the 1st trimester (and there is no evidence of a risk in later trimesters), and the possibility of foetal harm remains unknown.
Vitamin B1/ Thiamine is safe to use during lactation. Limited human data suggests that Vitamin B1/Thiamine does not represent a significant risk to the baby and in fact, the requirements for it are increased during lactation period.
Vitamin B1/Thiamine has no effect on the ability to drive.
Studies found that high doses of Vitamin B1/Thiamine may actually reverse the onset of early diabetic kidney disease.
Vitamin B1/Thiamine is given to alcoholic patients to prevent the development of Wernicke encephalopathy.