Progyluton Tablet 21s

Progyluton Tablet is a combined hormonal preparation belonging to the class of sequential hormone replacement therapy (HRT) medications, formulated to support hormonal balance in women. It contains two active ingredients — estradiol valerate and norgestrel — which work together as a sequential combination to address hormonal changes in the body. Like most hormonal medicines, Progyluton may cause some side effects in certain users, including nausea, headache, breast tenderness, and irregular spotting or breakthrough bleeding, particularly during the early weeks of use. If you are considering this medicine, it is completely normal to have questions about how it works, whether it is right for you, and what to watch out for — and we want you to feel informed and confident before you start. Always speak with your doctor or pharmacist before beginning any hormonal therapy, as individual health history plays an important role in determining suitability.

How to Take Progyluton Tablet

Progyluton Tablet is taken orally, once daily, following the specific sequential order of tablets as arranged in the calendar pack — it is important not to skip or rearrange the tablet sequence, as each tablet in the pack contains a different hormonal composition designed for a specific phase of your cycle. Swallow the tablet whole with a glass of water, with or without food, and try to take it at the same time each day to maintain consistent hormone levels. If you miss a dose, take it as soon as you remember within 12 hours; if more time has passed, skip the missed tablet and continue with the next one as scheduled.

Dosage of Progyluton Tablet

The standard recommended dosage of Progyluton Tablet is one tablet daily, taken continuously in the sequence provided within the 21-tablet calendar pack, followed by a 7-day tablet-free interval before starting the next pack. Your doctor may adjust the dosage schedule based on your individual hormonal needs and medical history, so always follow the specific instructions provided by your healthcare provider.

Shelf Life of Progyluton Tablet

Progyluton Tablet generally has a shelf life of 3 to 5 years from the date of manufacture, as indicated on the packaging. Always check the expiry date printed on the blister pack and outer carton before use, and do not consume the tablets if the expiry date has passed. Using expired hormonal tablets may result in reduced effectiveness and could potentially pose health risks.

How to Store Progyluton Tablet

• Store Progyluton Tablet at room temperature, below 25°C
• Keep the tablets in a dry place, away from direct sunlight, heat, and humidity — avoid storing in bathrooms or near kitchen sinks
• Keep the medicine in its original blister pack and carton to protect it from moisture and light
• Store out of reach of children and pets at all times
• Do not freeze the tablets
• If you notice any change in the appearance, colour, or texture of the tablets, do not use them and consult your pharmacist

Active Ingredient of Progyluton Tablet

Progyluton Tablet contains a sequential combination of two active hormonal ingredients:

• Estradiol Valerate 2 mg — a synthetic form of estradiol, a naturally occurring female estrogen hormone
• Norgestrel 0.5 mg — a synthetic progestogen (progestin) that complements the estrogen component in the second phase of the tablet pack

The pack is designed sequentially, with the first 11 tablets containing only estradiol valerate, and the remaining 10 tablets containing both estradiol valerate and norgestrel, mimicking a natural hormonal cycle pattern.

Side Effects of Progyluton Tablet

As with all hormonal medications, Progyluton Tablet may cause side effects in some individuals. Not everyone will experience these, and many side effects tend to improve after the first few weeks of use. Speak to your doctor if any of the following persist or concern you.

Common Side Effects:

• Nausea or mild stomach discomfort
• Headache or migraine
• Breast tenderness or swelling
• Irregular vaginal bleeding or spotting, especially during the first cycle
• Bloating or fluid retention
• Mood changes or emotional sensitivity
• Decreased libido

Less Common Side Effects:

• Weight changes (increase or decrease)
• Skin reactions such as rash or itching
• Changes in vaginal discharge
• Contact lens intolerance (due to fluid changes in the eye)
• Elevated blood pressure
• Dizziness or fatigue

Rare but Serious Side Effects (Seek Immediate Medical Attention):

• Signs of blood clots — sudden leg pain, swelling, or redness
• Chest pain or shortness of breath
• Sudden severe headache or visual disturbances
• Jaundice (yellowing of the skin or eyes)
• Signs of allergic reaction — severe rash, facial swelling, or difficulty breathing

Contraindications of Progyluton Tablet

Progyluton Tablet should not be used in individuals with any of the following conditions. Always disclose your full medical history to your doctor before starting this medication.

• Known or suspected pregnancy or breastfeeding
• Undiagnosed abnormal vaginal bleeding
• Known, suspected, or history of breast cancer or other estrogen-sensitive cancers (e.g., endometrial cancer)
• Active or history of venous thromboembolism (deep vein thrombosis, pulmonary embolism)
• Active or history of arterial thromboembolic disease (e.g., heart attack, stroke, angina)
• Severe liver disease or impaired liver function
• Known hypersensitivity to estradiol valerate, norgestrel, or any excipients in the formulation
• Porphyria (a rare metabolic disorder)
• Rotor syndrome or Dubin-Johnson syndrome (rare hereditary liver conditions)
• Otosclerosis with deterioration during previous pregnancy
• Severe diabetes with vascular complications

Drug & Food Interactions of Progyluton Tablet

It is important to inform your doctor or pharmacist about all medications, supplements, and herbal products you are currently taking, as Progyluton Tablet may interact with several substances.

Drug Interactions:

• Anticonvulsants (e.g., phenytoin, carbamazepine, phenobarbital) — may reduce the effectiveness of hormonal therapy by increasing its metabolism
• Rifampicin and other antibiotics (e.g., rifabutin) — may decrease plasma levels of hormonal components
• Antifungals (e.g., ketoconazole, itraconazole) — may increase hormone levels in the blood
• HIV medications / antiretrovirals (e.g., ritonavir, nelfinavir) — may alter hormonal metabolism
• Anticoagulants (e.g., warfarin) — hormonal therapy may affect anticoagulant activity; close monitoring required
• Thyroid medications — estrogen may affect thyroid-binding globulin levels, potentially requiring dosage adjustments
• Ciclosporin — estrogen may increase plasma levels of ciclosporin, increasing toxicity risk

Herbal & Supplement Interactions:

• St. John's Wort (Hypericum perforatum) — a commonly used herbal supplement that may significantly reduce the effectiveness of hormonal therapy
• High-dose Vitamin C supplements — may temporarily increase estrogen levels when taken simultaneously

Food Interactions:

• Grapefruit and grapefruit juice — may interfere with the metabolism of hormonal components by inhibiting liver enzymes, potentially increasing hormone levels in the blood
• Alcohol — excessive alcohol consumption may increase estrogen levels and elevate the risk of side effects

Quick Tips for Progyluton Tablet

• ✅ Always follow the sequential order of tablets in the pack — do not mix up or skip tablets as each phase contains a different hormonal dose
• ✅ Take your tablet at the same time every day to help maintain stable hormone levels and reduce the chance of side effects
• ✅ Do not stop taking Progyluton abruptly without consulting your doctor, as this may cause hormonal imbalance or withdrawal symptoms
• ✅ Keep the tablets in their original packaging — do not transfer them to other containers, as this may cause confusion with the sequential order
• ✅ Store away from heat and humidity — avoid leaving your medicine in the car, near windows, or in the bathroom
• ✅ Check the expiry date before starting a new pack — never use tablets that have expired
• ✅ Inform all your healthcare providers (including dentists and specialists) that you are taking hormonal therapy before any procedure or new prescription
• ✅ Do not share your medication with others, even if they appear to have similar symptoms — hormonal therapy is individually prescribed
• ✅ Dispose of unused or expired tablets responsibly — return them to a pharmacy for proper disposal rather than throwing them in household waste
• ✅ Keep a record of your pack start dates to help you track your cycle and ensure you begin each new pack on time

Frequently Asked Questions (FAQs) About Progyluton Tablet

Q1: Can I buy Progyluton Tablet online in Malaysia?
Yes, Progyluton Tablet is available for purchase through licensed online pharmacies in Malaysia. When buying online, always ensure that the pharmacy is registered with the Ministry of Health Malaysia (MOH) and operates under proper pharmaceutical regulations to guarantee product authenticity and safety.

Q2: Do I need a prescription to purchase Progyluton Tablet in Malaysia?
Yes, Progyluton Tablet is a prescription-only medicine (POM) in Malaysia. A valid prescription from a registered medical practitioner is required before purchase. Reputable online pharmacies in Malaysia will request a copy of your prescription as part of the ordering process — this is a sign of a trustworthy and legally compliant pharmacy.

Q3: How do I know if the Progyluton Tablet I am purchasing online is genuine?
To ensure authenticity, always purchase from a MOH-registered pharmacy or a licensed online pharmacy in Malaysia. Genuine Progyluton Tablets are manufactured by Bayer, a globally recognised pharmaceutical company. Check that the packaging includes proper batch numbers, manufacturing and expiry dates, and the manufacturer's details. If anything looks unusual about the packaging or tablets, do not use the product and contact the pharmacy immediately.

Q4: How long does delivery take when I order Progyluton Tablet online in Malaysia?
Delivery times vary depending on your location within Malaysia. Most licensed online pharmacies in Malaysia offer standard delivery within 3 to 5 working days for Peninsular Malaysia, while deliveries to Sabah and Sarawak may take slightly longer. Some pharmacies also offer express or same-day delivery options in selected areas. Check the pharmacy's delivery policy at checkout for the most accurate timeframe.

Q5: Is it safe to order Progyluton Tablet online in Malaysia?
Yes, it is safe — provided you order from a verified, licensed online pharmacy. Look for pharmacies that display their MOH registration number, have a secure website (https), provide a clear returns and refund policy, and offer access to a licensed pharmacist for consultation. Avoid purchasing from unverified social media sellers or websites that do not require a prescription, as counterfeit hormonal medicines pose serious health risks.

Q6: Can I get a refund or return if my Progyluton Tablet order arrives damaged or incorrect?
Most reputable online pharmacies in Malaysia have a returns and refund policy for damaged, incorrect, or defective products. However, due to the nature of pharmaceutical products, returns are generally only accepted if the item is unopened, undamaged, and reported within a specified timeframe (usually 24 to 48 hours upon receipt). Always check the pharmacy's returns policy before placing your order and keep your receipt or order confirmation as proof of purchase.

Q7: How will my Progyluton Tablet be packaged for delivery?
Licensed online pharmacies in Malaysia typically package medicines in discreet, sealed packaging to protect your privacy and ensure the product is not exposed to heat or moisture during transit. Pharmaceutical products like Progyluton are usually packed with appropriate cushioning to prevent damage during delivery.

Q8: What should I do if my Progyluton Tablet delivery is delayed or goes missing?
If your order is delayed beyond the estimated delivery window or appears to be missing, contact the online pharmacy's customer service team directly with your order number. Reputable pharmacies in Malaysia will be able to track your shipment and provide an update or arrange a replacement if necessary.

Q9: Can I purchase more than one pack of Progyluton Tablet at a time online?
The quantity you can purchase will depend on your prescription validity and the pharmacy's dispensing policy. In Malaysia, pharmacies are required to dispense prescription medicines in quantities that align with the prescription provided by your doctor. If you require multiple packs, ensure your prescription covers the required quantity, or consult your doctor for an updated prescription.

Q10: How should I store Progyluton Tablet after it has been delivered to my home?
Once received, store Progyluton Tablet at room temperature below 25°C, in a cool and dry place away from direct sunlight and moisture. Keep it in its original packaging and out of reach of children. Avoid storing it in the bathroom, kitchen, or inside a vehicle, as heat and humidity can affect the quality of the tablets.