Clobazam

Information About Clobazam

Uses of Clobazam

Clobazam is commonly used to treat adjunct in epilepsy, sedative, severe anxiety, short term anxiety

How Clobazam Works

Clobazam is a benzodiazepine. It enhances the inhibitory effects by binding to a receptor known as alpha�-aminobutyric acid type A receptor within the central nervous system.

Side Effects of Clobazam

Withdrawal symptoms (e.g. seizures, seizure exacerbation, status epilepticus, psychosis, hallucination, tremor, anxiety) Sedation, Anterograde amnesia, Suicidal ideation, Muscle weakness, Aggression, Drowsiness, Vomiting, Drooling, Constipation

Authorship

Written By

Dr Sri Viknarajan

MD (Universiti Hasanuddin, Indonesia)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Clobazam Related Warnings

Alcohol Not Advisable

It is unsafe to consume alcohol with clobazam due to its side effects such as dizziness, sedation and suicidal ideation.

Pregnancy Not Safe

Clobazam may be unsafe to use during pregnancy. It is not advisable to take the medication especially later stage of pregnancy as it can lead to physical dependence of neonate towards the medication and withdrawal syndrome. It can also lead to hypothermia, hypotonia and moderate respiratory depression.

Lactation Not Advisable

Clobazam is found in human milk. Therefore, it is not advisable for breastfeeding women to take the medication.

Driving Not advisable

Clobazam may cause side effects such as dizziness, somnolence, seizure which could affect your general attention and ability to concentrate whilst driving.

Kidney Use With Care

Dose adjustment of Clobazam may be needed. Please consult your doctor.

Liver Use With Care

In patients with liver disease, there are higher risk of adverse effects and responsiveness to Clobazam. Therefore, dose reduction may be necessary. Please consult your doctor.