Pravastatin

Information About Pravastatin

Uses of Pravastatin

Pravastatin is commonly used to treat patients with high cholesterol, high ldl levels, high triglycerides, and low hdl good cholesterol.

How Pravastatin Works

Pravastatin inhibits the 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, the enzyme catalyzing the early rate limiting step in cholesterol biosynthesis and inhibits LDL production by inhibiting the hepatic synthesis of VLDL- cholesterol, the LDL- cholesterol precursor.

Side Effects of Pravastatin

Nausea, vomiting, heartburn, Diarrhea, headache, cough, insomnia, chest pain, rash, fatigue, dizziness, influenza, blurred vision, myalgia, elevated serum transaminase, alopoecia, paraesthesia, impotence, gynaecomastia.

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Pravastatin Related Warnings

Alcohol Not Advisable

It is unsafe to consume alcohol with Pravastatin because it may worsen the side effects of Pravastatin such as nausea and vomiting, dizziness and visual disturbances.

Pregnancy Not Safe - High Risk

Pravastatin is unsafe to use during pregnancy. Both Animal and human studies have shown adverse effects on the fetus. The risk always outweigh the benefit of Pravastatin. Please consult your doctor.

Lactation Not Advisable

Pravastatin is contraindicated for breastfeeding mothers because a small amount of it is excreted in breast milk.

Driving Generally Safe

Pravastatin usually does not affect the ability to drive. Do not drive unless you are feeling well.

Kidney Use With Care

Pravastatin should be used with caution in patients with severe kidney disease. You should start the drug with 10 mg a day and further dose adjustment of Pravastatin may be needed. Please consult your doctor.

Liver Use With Care

Pravastatin should be used with caution in patients with severe liver disease. You should start Pravastatin with 10 mg a day and further dose adjustment of Pravastatin may be needed. Please consult your doctor.