Trimetazidine

Information About Trimetazidine

Uses of Trimetazidine

Trimetazidine is commonly used to treat angina heart related chest pain, heart attack, and heart failure.

How Trimetazidine Works

Trimetazidine inhibits B-oxidation of free fatty acid resulting in lowered oxygen demand for the heart. Also, it modulates cardiac metabolism without changing the hemodynamic functions and ensuring transmembrane sodium-potassium ionic pumps are functioning properly by increasing intracellular ATP levels.

Side Effects of Trimetazidine

Dizziness, Headache, Abdominal pain, Diarrhea , Nausea and vomiting, Rash, Palpitation, Postural hypotension

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Trimetazidine Related Warnings

Alcohol Not Advisable

It is not appropriate for you to take trimetazidine with alcohol intake because it may worsen the side effects of Trimetazidine such as dizziness, headache, nausea, and palpitations.

Pregnancy Not Safe

Trimetazidine may be unsafe to use during pregnancy. Animal studies have shown adverse reactions on the fetus, however, there are limited human studies. The benefits from use in pregnant mothers may be tolerable despite the risk. Please consult your doctor.

Lactation Limited Data

Trimetazidine is probably unsafe to use during lactation. Limited human data suggests that Trimetazidine should not be taken for the breastfeeding mothers unless necessary.

Driving Not advisable

Do not drive unless you are feeling well. Trimetazidine may cause side effects such as dizziness, headaches, nausea or palpitations, all of which could affect your ability to concentrate and drive.

Kidney Use With Care

Trimetazidine should be used with caution in patients with moderate and should not be used in severe kidney disease. Please consult your doctor.

Liver Limited Data

Trimetazidine should be used with caution in patients with liver disease due to its hepatic metabolism. Dose adjustment of Trimetazidine may be needed. Please consult your doctor.