Varenicline

Information About Varenicline

Uses of Varenicline

Varenicline is commonly used for quitting smoking, smoking addiction

How Varenicline Works

Varenicline is an alpha-4 beta-2 neuronal nicotinic acetylcholine receptor partial agonist which will compete with nicotine in cigarette to bind to the alpha-4 beta-2 receptor. Varenicline will act mildly at this site and relieve the withdrawal symptoms

Side Effects of Varenicline

Nausea, Gut disturbances, Headache , Sleepiness, Tiredness, Sleep disturbances, Increased appetite

Authorship

Written By

Dr Mohd Ramzdhan Bin Mohd Masdar

MD (Crimea State Medical University)

Reviewed By

Dr Nur Syuhada binti Zulkifli

MD, Universiti Kebangsaan Malaysia (UKM)

Varenicline Related Warnings

Alcohol Not Advisable

There is no known interaction between alcohol and Varenicline. There are reports showing the increase of intoxicating effects of alcohol with Varenicline treatment but the causal relationship has not been established. Thus, it is not advisable to consume alcohol with Varenicline simultaneously. Please consult your doctor.

Pregnancy Not Safe

Animal studies have shown reproductive toxicity but there are a moderate amount of data showing that there is no reproductive toxicity on pregnant women. It is preferable to exercise caution use of Varenicline during pregnancy.

Lactation Limited Data

Animal studies have shown Varenicline is excreted in breast milk but there are no data shown in breastfeeding mother. Thus, the decision has to be made whether to discontinue the medication or breastfeeding based on the benefit-risk ratio. Please consult your doctor.

Driving Not advisable

Do not drive unless you are feeling well. Varenicline may cause side effects such as dizziness, sleepiness and brief loss of consciousness, all of which could affect your ability to concentrate and drive.

Kidney Use With Care

No dose adjustment is needed in patients with mild to moderate kidney impairment. Caution use and dose adjustment may be required in patients with severe kidney impairment and patients requiring haemodialysis.

Liver Limited Data

Varenicline is safe to use in patients with liver impairment.