Nixoderm Ointment

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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Chong Zhan Pong
Written byDr. Chong Zhan PongDoctor of Medicine (MD), International Medical University (IMU)

Last updated:

Overview

Nixoderm Ointment is a topical skin ointment formulated with a combination of Benzoic Acid 6% w/w, Salicylic Acid 2.5% w/w, and Precipitated Sulphur 4.6% w/w in an ointment base. This particular combination of ingredients is part of a long-established category of topical ointments that has been sold in Malaysia for many years under the Nixoderm brand.

Nixoderm Ointment is classified as an OTC topical skin product and can be purchased through DoctorOnCall without a prescription. It is commonly sold in pack sizes of 5.34g and 17.7g, in a tube or jar format depending on the size selected.

As an ointment-based product, Nixoderm has a thicker, more occlusive texture than a cream or lotion, which is a characteristic of this product category rather than a statement about its effect. It is intended for localised application to small areas of skin rather than for use over large body surfaces.

Directions for Use

  • Wash and thoroughly dry the affected area of skin before application.
  • Apply a thin layer of Nixoderm Ointment directly to the area, using clean fingers or a cotton applicator.
  • Use once or twice daily, or as directed by your doctor or pharmacist.
  • Avoid applying to the eyes, lips, or other mucous membranes.
  • Wash your hands thoroughly after application, unless the hands are the area being treated.
  • Continue use for the duration recommended on the packaging or by your pharmacist, and stop if irritation develops.

Dosage

Nixoderm Ointment is for external, topical use only and does not have an oral or systemic dose. A thin layer applied once or twice daily to the affected area is the typical pattern of use described on the product packaging; do not apply more frequently than directed, as this does not speed up results and may increase the chance of skin irritation.

If there is no improvement in the appearance of the treated skin after a couple of weeks of regular use, or if the condition appears to worsen, stop self-treating and consult a doctor or pharmacist for further assessment.

Storage Instructions

Store Nixoderm Ointment below 30°C, in an airtight, tightly closed container, and protect it from light. Keep it in a cool, dry place away from direct sunlight and out of reach of children.

Side Effects

  • Common: mild burning, stinging, or warmth on the skin shortly after application.
  • Common: dryness, peeling, or flaking of the treated skin with regular use.
  • Uncommon: redness or localised irritation that extends beyond the area of application.
  • Uncommon: a noticeable sulphur-like odour on the skin or clothing after application.
  • Rare: allergic contact dermatitis in individuals sensitive to one of the ingredients, which would need medical attention.

Contraindications

  • Known hypersensitivity to benzoic acid, salicylic acid, sulphur, or other salicylate compounds.
  • Broken, infected, or actively bleeding skin, unless a doctor or pharmacist has specifically advised otherwise.
  • Use on the face, near the eyes, or on other sensitive or mucous-membrane areas without first checking with a pharmacist.
  • Use over large areas of the body, which increases the amount of salicylic acid absorbed through the skin.

Drug / Food Interactions

  • Applying Nixoderm Ointment together with other topical products containing salicylic acid, benzoyl peroxide, or retinoids on the same area of skin may increase the combined risk of irritation and dryness.
  • There is a theoretical increased risk of salicylate absorption if used extensively alongside oral salicylate medicines, such as aspirin, so check with a pharmacist if you are on regular oral salicylate treatment.
  • No clinically significant food interactions are established for this topical product.

Quick Tips

  • Apply only a thin layer — a thicker layer does not work faster and raises the risk of irritation.
  • Always wash and dry the area before each application.
  • Avoid covering the treated area with airtight dressings unless advised by a pharmacist.
  • Keep the ointment away from the eyes, lips, and other mucous membranes.
  • Do a small patch test first if you have not used this product before and have sensitive skin.
  • Wash your hands after application to avoid accidentally transferring the ointment to your eyes or other areas.

Ingredients / Active Ingredients

  • Benzoic Acid 6% w/w
  • Salicylic Acid 2.5% w/w
  • Precipitated Sulphur 4.6% w/w
  • Supplied in an ointment base intended for external application.

Relevant Information

Precautions: Use Nixoderm Ointment only on the area of skin it is intended for, and avoid applying it over large areas of the body or under occlusive dressings, as this can increase absorption of its ingredients. Pregnant or breastfeeding individuals and parents considering use on children should check with a pharmacist or doctor first, as salicylic acid absorption may be a consideration in these groups.

When to See a Doctor or Pharmacist: See a doctor or pharmacist if the treated area does not show improvement after a couple of weeks of consistent use, if the skin becomes more irritated, swollen, or painful, or if you notice signs of a wider allergic reaction such as spreading rash or swelling.

Frequently Asked Questions

Product Specifications

ClassificationNon-prescription
Weight17.7g, 5.34g
Shelf LifeUse Nixoderm Ointment before the expiry date printed on the tube, jar, or outer packaging. Do not use the product beyond this date, even if it appears visually unchanged.

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