Norvasc 10mg Tablet

Norvasc 10mg Tablet is the original Pfizer brand of amlodipine at its highest standard strength, prescribed for adults with high blood pressure or angina whose condition has not been adequately controlled on the lower 5mg dose. As a dihydropyridine calcium channel blocker, amlodipine relaxes blood vessels to reduce blood pressure and improve blood flow to the heart muscle, and the 10mg strength represents the maximum recommended daily dose for most adult patients.

Norvasc 10mg is a prescription-only medicine, and because it is typically reached only after a period of treatment and dose review, it requires a doctor’s ongoing assessment. Through DoctorOnCall, customers requiring Norvasc 10mg complete an online consultation so a doctor can confirm the appropriateness of this higher strength before a prescription is issued and the order is processed.

Amlodipine selectively blocks the entry of calcium into vascular smooth muscle cells through L-type calcium channels, causing sustained relaxation of the muscle in blood vessel walls. At the 10mg strength, this vasodilation produces a stronger and more sustained reduction in peripheral vascular resistance than the 5mg dose, which is why it is generally reserved for patients whose blood pressure or angina symptoms persist despite treatment with the lower strength.

Take Norvasc 10mg once daily, at approximately the same time each day, with or without food, and swallow the tablet whole with water. This strength is usually reached by up-titration from a lower dose under medical supervision, so do not switch to the 10mg strength on your own without your doctor’s specific instruction.

10mg once daily is the maximum recommended dose of amlodipine for most adults, typically prescribed after a doctor has reviewed the patient’s response to the 5mg dose and determined that a higher strength is needed for adequate blood pressure or angina control. Because dose-related side effects such as ankle swelling tend to be more noticeable at this higher strength, regular follow-up is important, and any further adjustment should only be made by your prescribing doctor.

Norvasc tablets are typically stable for up to 36 months from the date of manufacture when stored unopened in original packaging; always check the expiry date printed on the blister or carton before use.

Store below 30°C in a dry place away from direct sunlight and moisture, and keep out of reach of children. Keep the tablets in their original packaging until ready for use.

• Known hypersensitivity to amlodipine or other dihydropyridine calcium channel blockers
• Severe hypotension (very low blood pressure)
• Severe aortic stenosis (narrowing of the aortic valve)
• Cardiogenic shock or haemodynamically unstable heart failure
• Unstable angina, other than vasospastic angina, where amlodipine may still be used under specialist guidance

• Grapefruit juice can increase amlodipine blood levels in some individuals and is best avoided or limited, particularly at this higher strength
• Strong CYP3A4 inhibitors, such as certain antifungals (ketoconazole) or antivirals, may increase amlodipine levels and the risk of side effects
• Simvastatin doses above a certain limit should be avoided when combined with amlodipine due to an increased risk of muscle-related side effects
• Other blood pressure medicines may have an additive blood-pressure-lowering effect, increasing the risk of hypotension
• NSAIDs taken regularly may reduce the blood-pressure-lowering effect of amlodipine

• Take Norvasc 10mg at the same time each day to maintain consistent blood pressure or angina control
• Monitor for ankle or foot swelling, which is more common at this higher strength, and report bothersome swelling to your doctor
• Do not increase your own dose beyond what your doctor has prescribed
• Limit or avoid grapefruit juice while on treatment
• Attend follow-up appointments so your doctor can confirm this strength continues to be appropriate for you

Norvasc 10mg represents the top of the standard amlodipine dosing range and is generally used only after a doctor has reviewed a patient’s response to a lower dose. Because dose-related effects such as ankle swelling are more common at this strength, patients on 10mg should maintain regular follow-up so their doctor can weigh continued benefit against tolerability over time.