Sifrol Extended Release 0.375mg Tablet
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Overview
Sifrol Extended Release 0.375mg Tablet contains pramipexole 0.375mg in a extended-release (once-daily) formulation, a non-ergot dopamine agonist used to treat the signs and symptoms of Parkinson’s disease, either alone or in combination with levodopa. It may also be used to treat moderate-to-severe restless legs syndrome, depending on the strength and formulation prescribed.
Pramipexole works by directly stimulating dopamine D2 and D3 receptors in the brain, mimicking the action of dopamine, which is deficient in Parkinson’s disease. This helps improve movement control, tremor, stiffness, and slowness of movement.
How it Works
Pramipexole binds to and activates dopamine D2-family receptors (particularly D3 receptors) in the brain, directly substituting for the deficient natural dopamine signalling seen in Parkinson’s disease, which helps restore smoother motor control.
Directions for Use
Take Sifrol Extended Release 0.375mg Tablet once daily, at about the same time each day, and swallow the tablet whole without crushing or chewing it, as this is an extended-release formulation. Do not stop this medicine suddenly without your doctor’s advice, as abrupt withdrawal can cause withdrawal symptoms or, rarely, a fever and confusion resembling neuroleptic malignant syndrome.
Dosage
Treatment usually starts at a low dose and is gradually increased (titrated) over several weeks under close medical supervision, based on your response and tolerability, until an effective dose is reached. Your doctor will determine your specific starting dose, titration schedule, and maintenance dose.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Nausea or upset stomach
- Drowsiness or dizziness
- Headache
- Dry mouth
- Constipation
- Hallucinations (rare but serious)
- Swelling of arms or legs
- Sudden sleep episodes
Contraindications
- Known hypersensitivity to pramipexole or any component of this product
- Use with caution in patients with severe kidney impairment (dose adjustment needed)
- Use with caution in patients with a history of psychotic disorders
Drug / Food Interactions
- Other dopaminergic medicines (e.g. levodopa) may enhance both effect and side effects
- Antipsychotic medicines that block dopamine receptors may reduce the effectiveness of pramipexole
- Sedating medicines or alcohol may increase drowsiness
- Cimetidine may increase blood levels of pramipexole
Quick Tips
- Be cautious about driving or operating machinery, as this medicine can cause sudden episodes of falling asleep without warning
- Tell your doctor immediately if you or your family notice new compulsive behaviours such as gambling, shopping, or binge eating
- Do not stop this medicine abruptly without medical advice
- Rise slowly from sitting or lying down to reduce dizziness
Frequently Asked Questions
What is Sifrol Extended Release 0.375mg Tablet used for?
It is used to treat the signs and symptoms of Parkinson’s disease.
How does pramipexole work?
It directly stimulates dopamine receptors in the brain, mimicking the natural dopamine that is deficient in Parkinson’s disease.
Why does my dose need to be increased gradually?
Titrating the dose slowly helps your body adjust and reduces the risk of side effects like nausea and low blood pressure.
Can this medicine make me fall asleep suddenly?
Yes, some people experience sudden sleep episodes without warning. Use caution when driving or operating machinery until you know how this medicine affects you.
What are the common side effects?
Nausea, drowsiness, dizziness, and hallucinations (particularly in older adults) are commonly reported.
Can this medicine cause unusual behaviour changes?
Yes, some people develop impulse control problems such as compulsive gambling, shopping, or eating. Report any such changes to your doctor promptly.
Do I need to swallow the tablet whole?
Yes, this extended-release tablet must be swallowed whole – do not crush, chew, or split it, as this could affect how the medicine is released.
Can I buy Sifrol Extended Release 0.375mg Tablet from DoctorOnCall?
Yes, Sifrol Extended Release 0.375mg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Sifrol Extended Release 0.375mg Tablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Sifrol Extended Release 0.375mg Tablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Sifrol Extended Release 0.375mg Tablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Sifrol Extended Release 0.375mg Tablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Sifrol Extended Release 0.375mg Tablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Pramipexole 0.375mg (extended-release)
Safety Advice
Pregnancy
This medicine should only be used during pregnancy if prescribed by a doctor after careful evaluation.
Breastfeeding
Limited data on excretion in breast milk. Consult a doctor before use.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Generally safe, but caution may be required in some patients.
Alcohol
It is not advisable to consume alcohol while taking this medicine.
Driving
Use caution while driving until you know how this medicine affects you.
Medical Review
