Sifrol Extended Release 0.375mg Tablet

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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Chong Zhan Pong
Written byDr. Chong Zhan PongDoctor of Medicine (MD), International Medical University (IMU)

Last updated:

Overview

Sifrol Extended Release 0.375mg Tablet is a prescription-only medicine (POM) that contains Pramipexole 0.375mg (extended-release). It is supplied as a tablet and is dispensed in Malaysia only against a valid prescription issued by a registered doctor.

Under Malaysian rules for prescription medicines, this page carries product, safety and handling information only. Your doctor or pharmacist will explain whether this medicine is suitable for you, the dose you should take, and how long you should take it.

On DoctorOnCall, Sifrol Extended Release 0.375mg Tablet is reviewed by a licensed doctor through an online consultation and dispensed by a registered pharmacist before delivery. Always follow the instructions on your prescription label and the package insert supplied with the product, and do not share this medicine with anyone else.

Directions for Use

Take Sifrol Extended Release 0.375mg Tablet once daily, at about the same time each day, and swallow the tablet whole without crushing or chewing it, as this is an extended-release formulation. Do not stop this medicine suddenly without your doctor’s advice, as abrupt withdrawal can cause withdrawal symptoms or, rarely, a fever and confusion resembling neuroleptic malignant syndrome.

Dosage

Treatment usually starts at a low dose and is gradually increased (titrated) over several weeks under close medical supervision, based on your response and tolerability, until an effective dose is reached. Your doctor will determine your specific starting dose, titration schedule, and maintenance dose.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Nausea or upset stomach
  • Drowsiness or dizziness
  • Headache
  • Dry mouth
  • Constipation
  • Hallucinations (rare but serious)
  • Swelling of arms or legs
  • Sudden sleep episodes

Contraindications

  • Known hypersensitivity to pramipexole or any component of this product
  • Use with caution in patients with severe kidney impairment (dose adjustment needed)
  • Use with caution in patients with a history of psychotic disorders

Drug / Food Interactions

  • Other dopaminergic medicines (e.g. levodopa) may enhance both effect and side effects
  • Antipsychotic medicines that block dopamine receptors may reduce the effectiveness of pramipexole
  • Sedating medicines or alcohol may increase drowsiness
  • Cimetidine may increase blood levels of pramipexole

Quick Tips

  • Be cautious about driving or operating machinery, as this medicine can cause sudden episodes of falling asleep without warning
  • Tell your doctor immediately if you or your family notice new compulsive behaviours such as gambling, shopping, or binge eating
  • Do not stop this medicine abruptly without medical advice
  • Rise slowly from sitting or lying down to reduce dizziness

Ingredients / Active Ingredients

  • Pramipexole 0.375mg (extended-release)

Safety Advice

Pregnancy

Safe If Prescribed

This medicine should only be used during pregnancy if prescribed by a doctor after careful evaluation.

Breastfeeding

Limited Data

Limited data on excretion in breast milk. Consult a doctor before use.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Generally Safe

Generally safe, but caution may be required in some patients.

Alcohol

Not Advisable

It is not advisable to consume alcohol while taking this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Frequently Asked Questions

Product Specifications

BrandBoehringer Ingelheim
ClassificationPrescription medicine
Ingredients / Active IngredientsPramipexole
Pack Size30s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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