Agrylin 500mcg Capsule
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Prescription Required
Overview
Agrylin 500mcg Capsule contains anagrelide hydrochloride 500mcg, a platelet-lowering medicine used to treat essential thrombocythaemia, a blood disorder in which the bone marrow produces too many platelets, increasing the risk of abnormal blood clotting or bleeding. It is prescribed and monitored by a haematology specialist.
Anagrelide reduces platelet count by interfering with the maturation of megakaryocytes, the bone marrow cells that produce platelets, lowering the number of new platelets released into the bloodstream over time.
How it Works
Anagrelide selectively inhibits the maturation of megakaryocytes into platelet-producing cells at a late stage of their development, without significantly affecting red or white blood cell production. This gradually reduces the platelet count over 7-14 days of treatment.
Directions for Use
Take Agrylin 500mcg Capsule exactly as prescribed by your haematology specialist, at the same times each day. Swallow the capsule whole with water, and attend all scheduled blood tests and cardiac monitoring appointments, as your dose depends on close follow-up.
Dosage
The starting dose of Agrylin 500mcg Capsule is usually 0.5mg (500mcg) once or twice daily, individualised and titrated by your haematology specialist based on regular platelet count monitoring, with careful cardiac assessment before and during treatment.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Headache
- Dizziness
- Nausea
- Diarrhoea
- Fast or irregular heartbeat
- Shortness of breath
- Fluid retention or swelling (especially in the ankles or legs)
- Fatigue
Contraindications
- Known hypersensitivity to anagrelide
- Severe hepatic or renal impairment
- Significant pre-existing heart disease, unless carefully assessed and monitored by a specialist
- Pregnancy, unless the benefit clearly outweighs the risk as determined by your specialist
Drug / Food Interactions
- Other medicines that lower platelet count or affect bone marrow function may have additive effects requiring closer monitoring
- Aspirin or NSAIDs combined with anagrelide can increase the risk of bleeding, especially as platelet counts fall
- Sucralfate may reduce the absorption of anagrelide if taken at the same time
- Strong CYP1A2 inhibitors (e.g. fluvoxamine) may increase anagrelide blood levels
Quick Tips
- Attend every scheduled blood test and cardiac check, as your dose is adjusted based on these results
- Report palpitations, chest pain, or shortness of breath to your haematology team immediately
- Avoid taking aspirin or NSAIDs without checking with your doctor first, due to increased bleeding risk
- Never adjust your own dose without your haematology specialist’s guidance
Frequently Asked Questions
What is Agrylin 500mcg Capsule used for?
Agrylin 500mcg Capsule is used to lower an abnormally high platelet count in essential thrombocythaemia, reducing the risk of abnormal blood clotting or bleeding, under haematology specialist supervision.
Why do I need heart monitoring while taking this medicine?
Anagrelide can affect heart rhythm and function in some patients, so your specialist will assess your heart before starting treatment and monitor it periodically throughout, especially if you notice palpitations or chest symptoms.
How long does it take for my platelet count to come down?
Platelet counts typically begin to fall within about 7-14 days of starting treatment, though your specialist will confirm your individual response through blood tests.
Can I take aspirin while on this medicine?
Combining aspirin or other NSAIDs with anagrelide can increase bleeding risk, particularly as your platelet count falls. Always check with your haematology specialist before taking any new medicine, including over-the-counter products.
What should I do if I miss a dose of Agrylin 500mcg Capsule?
Contact your haematology specialist for guidance if you miss a dose, rather than adjusting your own schedule, since your dose is carefully individualised based on monitoring.
Can I buy Agrylin 500mcg Capsule from DoctorOnCall?
Yes, Agrylin 500mcg Capsule is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Agrylin 500mcg Capsule according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Agrylin 500mcg Capsule?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Agrylin 500mcg Capsule cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Agrylin 500mcg Capsule?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Agrylin 500mcg Capsule?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Anagrelide hydrochloride 500mcg
Safety Advice
Pregnancy
Use during pregnancy is generally not recommended unless absolutely necessary.
Breastfeeding
Use with caution. Monitor infant for potential adverse reactions.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Use cautiously. Liver function monitoring may be required.
Alcohol
It is not advisable to consume alcohol while taking this medicine.
Driving
Use caution while driving until you know how this medicine affects you.
Medical Review
