Apo-Isosorbide Dinitrate 10mg Tablet
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Overview
Apo-Isosorbide Dinitrate 10mg Tablet contains isosorbide dinitrate 10mg, a long-acting nitrate vasodilator used to prevent and treat angina (chest pain) caused by coronary artery disease.
Angina occurs when the heart muscle does not get enough oxygen-rich blood, often during exertion. Isosorbide dinitrate works by relaxing and widening blood vessels, particularly veins, which reduces the amount of blood returning to the heart and lowers the heart’s oxygen demand, while also modestly dilating the coronary arteries.
How it Works
Isosorbide dinitrate is converted in the body to nitric oxide, which relaxes vascular smooth muscle. This widens veins (reducing preload on the heart) and, to a lesser extent, arteries, easing the heart’s workload and reducing the frequency and severity of angina episodes.
Directions for Use
Take Apo-Isosorbide Dinitrate 10mg Tablet exactly as scheduled by your doctor, usually before situations known to trigger angina (such as exertion). Swallow the tablet whole with water. Do not stop this medicine suddenly, and sit down if you feel dizzy or light-headed after a dose.
Dosage
Apo-Isosorbide Dinitrate 10mg Tablet dosing is individualised by your doctor based on the pattern and severity of your angina, typically taken several times daily with a nitrate-free interval each day to prevent tolerance from developing. Follow your doctor’s specific schedule rather than adjusting the timing yourself.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Headache
- Dizziness or lightheadedness
- Flushing (warmth, redness, or tingly feeling under the skin)
- Nausea
- Low blood pressure
- Tiredness or weakness
Contraindications
- Known hypersensitivity to nitrates
- Concomitant use with PDE5 inhibitors (e.g. sildenafil, tadalafil) or riociguat, due to risk of severe, life-threatening low blood pressure
- Severe low blood pressure or uncorrected low blood volume
- Severe anaemia
- Angle-closure glaucoma
Drug / Food Interactions
- PDE5 inhibitors (sildenafil, tadalafil, vardenafil) must never be combined with this medicine due to severe hypotension risk
- Alcohol can worsen dizziness and low blood pressure
- Other blood pressure-lowering medicines may increase the risk of hypotension
Quick Tips
- Sit or lie down if you feel dizzy after taking a dose
- Never combine this medicine with erectile dysfunction medicines – tell every doctor you see that you take a nitrate
- Keep a consistent daily schedule, including any nitrate-free period your doctor has set, to prevent your body building tolerance
- Seek urgent medical attention if chest pain does not ease with rest or your usual medicine
Frequently Asked Questions
What is Apo-Isosorbide Dinitrate 10mg Tablet used for?
Apo-Isosorbide Dinitrate 10mg Tablet is used to prevent and treat angina (chest pain) caused by reduced blood flow to the heart in coronary artery disease.
Why do I get headaches after taking this medicine?
Headaches are a common and expected side effect caused by the widening of blood vessels, including those in the head. They often lessen as your body adjusts, but tell your doctor if they are severe or persistent.
Why can’t I take this medicine with erectile dysfunction medicines?
Combining nitrates like isosorbide dinitrate with PDE5 inhibitors such as sildenafil can cause a severe, potentially life-threatening drop in blood pressure. Always tell any doctor prescribing you medicine that you are on a nitrate.
Why does my doctor want me to have a nitrate-free period each day?
Taking nitrates continuously without a break can lead to reduced effectiveness (tolerance) over time. A nitrate-free interval, usually overnight, helps maintain the medicine’s effect.
What should I do if I miss a dose of Apo-Isosorbide Dinitrate 10mg Tablet?
Take the missed dose as soon as you remember, unless it is almost time for your next dose – in that case, skip the missed dose and continue your regular schedule. Do not double the dose.
Can I buy Apo-Isosorbide Dinitrate 10mg Tablet from DoctorOnCall?
Yes, Apo-Isosorbide Dinitrate 10mg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Apo-Isosorbide Dinitrate 10mg Tablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Apo-Isosorbide Dinitrate 10mg Tablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Apo-Isosorbide Dinitrate 10mg Tablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Apo-Isosorbide Dinitrate 10mg Tablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Apo-Isosorbide Dinitrate 10mg Tablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Isosorbide dinitrate 10mg
Safety Advice
Pregnancy
This medicine should only be used during pregnancy if prescribed by a doctor after careful evaluation.
Breastfeeding
Limited data on excretion in breast milk. Consult a doctor before use.
Kidney
Generally safe, but caution may be required in some patients.
Liver
Generally safe, but caution may be required in some patients.
Alcohol
It is not advisable to consume alcohol while taking this medicine.
Driving
Use caution while driving until you know how this medicine affects you.
Medical Review
