Certican 0.25mg Tablet

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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Chong Zhan Pong
Written byDr. Chong Zhan PongDoctor of Medicine (MD), International Medical University (IMU)

Last updated:

Overview

Certican 0.25mg Tablet contains Everolimus 0.25mg and is available as a tablet. It is classified as a prescription medicine and may only be obtained with a valid prescription from a registered medical practitioner.

Only product, safety and handling information is published here. Anything beyond that is explained to you directly by your doctor or pharmacist as part of your consultation.

DoctorOnCall is a licensed online pharmacy. Orders for Certican 0.25mg Tablet are processed only after a doctor has assessed your suitability and issued a prescription, and every order is checked by a registered pharmacist before it is sent out.

Directions for Use

Take Certican 0.25mg Tablet consistently, either always with food or always without food (as advised by your transplant team), at the same times each day approximately 12 hours apart, and always alongside your other prescribed immunosuppressants. Swallow the tablet(s) whole with water. Attend every scheduled blood test to monitor your everolimus levels, kidney and liver function, and blood counts, as your transplant team uses these results to fine-tune your dose.

Dosage

The dose of Certican 0.25mg Tablet is individualised precisely by your transplant specialist based on regular blood tests measuring your everolimus levels, together with your kidney and liver function, your other immunosuppressant doses, and your clinical response. It is usually taken twice daily, exactly as prescribed. Never adjust your own dose or stop taking this medicine without your transplant team’s explicit instruction, as this can put your transplanted organ at risk of rejection.

Storage Instructions

Store below 25°C in the original blister pack to protect the tablets from light and moisture. Do not remove a tablet from the blister until immediately before you take it, and keep out of reach of children.

Side Effects

  • Mouth ulcers or sores
  • Weakness or fatigue
  • Nausea or loss of appetite
  • Diarrhea
  • Increased risk of infections
  • Skin rash
  • Headache
  • Swelling of hands, feet, or legs
  • Cough or breathing issues

Contraindications

  • Known hypersensitivity to everolimus, sirolimus, or any ingredient in this product
  • Use without close specialist transplant-team supervision and regular blood monitoring
  • Severe, uncontrolled active infection
  • Live vaccines should not be given during treatment – check with your transplant team before any vaccination

Drug / Food Interactions

  • Potent CYP3A4/P-glycoprotein inhibitors (e.g. ketoconazole, ritonavir, clarithromycin) can markedly increase everolimus blood levels
  • Potent enzyme inducers (e.g. rifampicin, carbamazepine, St John’s Wort) can reduce everolimus blood levels
  • Grapefruit and grapefruit juice must be avoided completely, as they can significantly raise everolimus levels
  • Other immunosuppressants such as ciclosporin have important interactions with everolimus that your transplant team manages as part of your overall regimen

Quick Tips

  • Never skip a scheduled blood test – your dose depends on the results
  • Avoid grapefruit and grapefruit juice completely
  • Check with your transplant team before receiving any vaccination, especially live vaccines
  • Report any fever, infection symptoms, unusual bruising, or bleeding to your transplant team promptly
  • Never adjust your dose or stop this medicine on your own

Ingredients / Active Ingredients

  • Everolimus 0.25mg

Safety Advice

Pregnancy

Not Safe

This medicine is not considered safe during pregnancy and should be avoided.

Breastfeeding

Not Advisable

Generally not recommended while breastfeeding.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Frequently Asked Questions

Product Specifications

BrandNovartis
ClassificationPrescription medicine
Ingredients / Active IngredientsEverolimus
Pack Size60s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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