Comtan 200mg Tablet

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Manufacturer Novartis
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Comtan 200mg Tablet is a prescription-only medicine (POM) presented as a tablet, with Entacapone 200mg as its active ingredient content.

This page is limited to product, safety and handling information, in line with Malaysian rules on prescription medicine information for the public. Your prescriber or pharmacist is the right source for anything beyond that, together with the leaflet inside the pack.

Through DoctorOnCall, this product is supplied after an online consultation with a licensed doctor and a valid prescription, and it is checked by a registered pharmacist before dispensing. Take it exactly as prescribed, and speak to your doctor before stopping, changing the dose, or starting any other medicine alongside it.

Directions for Use

Take Comtan 200mg Tablet at the same time as each dose of your levodopa-containing medicine – it will not work if taken alone or at different times, since it only prolongs levodopa’s effect when present together in the body. You may notice your urine turns a reddish-brown colour, which is a harmless effect of the medicine.

Dosage

Comtan 200mg Tablet is taken as one tablet (200mg) together with each dose of levodopa/carbidopa or levodopa/benserazide, up to a maximum of 10 tablets (2000mg) per day. Your neurologist will determine how many doses you need per day and may adjust your levodopa dose when starting entacapone, as it increases levodopa’s effect.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Nausea or vomiting
  • Diarrhoea
  • Dizziness or light-headedness
  • Abdominal pain
  • Fatigue
  • Discolouration of urine (reddish-brown, usually harmless)
  • Increased movements or shaking (dyskinesia)

Contraindications

  • Known hypersensitivity to entacapone or any ingredient in this product
  • Severe liver impairment
  • Phaeochromocytoma (a tumour that can cause dangerous swings in blood pressure)
  • History of neuroleptic malignant syndrome or non-traumatic rhabdomyolysis
  • Concomitant use with non-selective monoamine oxidase (MAO) inhibitors

Drug / Food Interactions

  • Non-selective MAO inhibitors must not be combined with entacapone
  • Iron supplements can reduce entacapone absorption if taken at the same time – space doses at least 2-3 hours apart
  • Drugs metabolised by COMT (e.g. methyldopa, isoprenaline, adrenaline) may have an enhanced effect
  • Other medicines that cause drowsiness may add to sedation when combined with entacapone-related dyskinesia management

Quick Tips

  • Always take this medicine together with your levodopa dose, never on its own
  • Do not stop this medicine suddenly without your neurologist’s guidance
  • Do not be alarmed if your urine turns reddish-brown – this is a normal, harmless effect
  • Report any new confusion, hallucinations, or worsening involuntary movements to your neurologist promptly

Ingredients / Active Ingredients

  • Entacapone 200mg

Safety Advice

Pregnancy

Use With Care

This medicine should be used cautiously during pregnancy. Monitoring may be required.

Breastfeeding

Limited Data

Limited data on excretion in breast milk. Consult a doctor before use.

Kidney

Generally Safe

Generally safe, but caution may be required in some patients.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Frequently Asked Questions

Product Specifications

BrandNovartis
ManufacturerNovartis
ClassificationPrescription medicine
Ingredients / Active IngredientsEntacapone
Pack Size100s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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