Daxas 500mcg Tablet
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Prescription Required
Overview
Daxas 500mcg Tablet contains roflumilast 500mcg, a selective phosphodiesterase-4 (PDE4) inhibitor used under specialist supervision to reduce the risk of flare-ups (exacerbations) in adults with severe chronic obstructive pulmonary disease (COPD) associated with chronic bronchitis and a history of frequent exacerbations. It is not a bronchodilator and does not relieve sudden breathing difficulty.
Roflumilast works by reducing lung inflammation at a cellular level rather than opening the airways directly, so it is taken alongside – never in place of – your regular COPD inhalers and bronchodilators as prescribed by your specialist.
How it Works
Roflumilast inhibits the PDE4 enzyme, increasing intracellular cyclic AMP within inflammatory and structural lung cells. This reduces the release of inflammatory mediators associated with COPD, which over time lowers the frequency of exacerbations, but this anti-inflammatory action does not provide immediate bronchodilation.
Directions for Use
Take Daxas 500mcg Tablet at the same time each day, with or without food, and continue all your other prescribed COPD medicines and inhalers exactly as directed. Do not stop any of your regular COPD treatments without your specialist’s advice, even if your breathing feels stable.
Dosage
The usual dose of Daxas 500mcg Tablet is one tablet once daily, taken long-term as a maintenance treatment under the supervision of a respiratory specialist. It is not used for sudden worsening of breathing and does not replace your rescue inhaler or other prescribed COPD medicines.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Nausea
- Diarrhea
- Headache
- Weight loss
- Dizziness
- Insomnia
- Decreased appetite
- Abdominal pain
Contraindications
- Moderate to severe liver impairment
- Known hypersensitivity to roflumilast or any ingredient in this product
- A history of untreated depression with suicidal thoughts or behaviour
- Pregnancy and breastfeeding, unless specifically advised by your specialist
Drug / Food Interactions
- Strong enzyme-inducing medicines such as rifampicin, phenobarbital, carbamazepine, and phenytoin can reduce roflumilast’s effectiveness
- Strong enzyme-inhibiting medicines such as ketoconazole and fluvoxamine can increase roflumilast exposure and side effects
- Theophylline should be combined only with caution and close monitoring, as data on this combination are limited
- Certain hormonal contraceptives (e.g. containing gestodene and ethinylestradiol) may have altered levels when combined
Quick Tips
- Always continue your other prescribed COPD medicines and inhalers – this medicine works alongside them, not instead of them
- Weigh yourself periodically and tell your specialist about any significant, unintended weight loss
- Report any new mood changes, anxiety, or feelings of hopelessness to your doctor immediately
- Do not use this medicine for sudden breathlessness – use your rescue inhaler and seek medical help as advised
Frequently Asked Questions
Is Daxas 500mcg Tablet a reliever inhaler for sudden breathlessness?
No, roflumilast is not a bronchodilator and does not act quickly. It is a long-term maintenance treatment used alongside your regular inhalers to reduce how often COPD flare-ups occur.
Why does my specialist need to monitor my mood while I take Daxas 500mcg Tablet?
Roflumilast has been associated with psychiatric side effects such as anxiety, low mood, and, rarely, suicidal thoughts in some patients, so any new or worsening mood symptoms should be reported and reviewed promptly.
Will Daxas 500mcg Tablet cause weight loss?
Some patients experience decreased appetite and weight loss while taking roflumilast. Your specialist will monitor your weight during treatment, and you should report any significant or unintended weight loss.
How soon will I notice fewer COPD flare-ups?
The benefit of roflumilast in reducing exacerbations builds up over months of consistent use as part of your overall COPD management plan, rather than providing an immediate effect.
Can I stop my other COPD inhalers once I start Daxas 500mcg Tablet?
No, you must continue all other prescribed COPD medicines and inhalers exactly as directed by your specialist; roflumilast is an add-on treatment, not a replacement.
Can I buy Daxas 500mcg Tablet from DoctorOnCall?
Yes, Daxas 500mcg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Daxas 500mcg Tablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Daxas 500mcg Tablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Daxas 500mcg Tablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Daxas 500mcg Tablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Daxas 500mcg Tablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Roflumilast 500mcg
Safety Advice
Pregnancy
Use during pregnancy is generally not recommended unless absolutely necessary.
Breastfeeding
This medicine is generally safe during breastfeeding with minimal risk to the infant.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Not recommended in patients with liver disease.
Alcohol
It is not advisable to consume alcohol while taking this medicine.
Driving
Use caution while driving until you know how this medicine affects you.
Medical Review
