Hepatic Encephalopathy

Medical Review

Written by: Dr. Von Chiao Wen Doctor of Medicine (MD), N.I. Pirogov Russian National Research Medical University
Reviewed by: Dr. Lee Chin Meng Doctor of Medicine (MD), Manipal Academy of Higher Education (MAHE)

Overview of Hepatic Encephalopathy

Hepatic encephalopathy is a condition where the brain function declines due to severe liver disease causing the build-up of toxins entering the bloodstream which eventually affects the brain and it can cause mortality if it is not resolved quickly.

Signs and Symptoms of Hepatic Encephalopathy

Difficulty thinking, Personality changes, Poor concentration, Problems with handwriting or loss of other small hand movements, Confusion, Forgetfulness, Anxiety, Seizures, Severe personality changes

Common Causes of Hepatic Encephalopathy

Infections such as pneumonia, Kidney problems, Dehydration, Hypoxia or low oxygen levels, Recent surgery or trauma, Medications that suppress your immune system, Eating too much protein, Medications that suppress your central nervous system such as barbiturates or benzodiazepine tranquilizers, Electrolyte imbalance

Risk Factors of Hepatic Encephalopathy

Cirrhosis, Hypovolemia, GI bleeding, Hypokalemia, Metabolic alkalosis, Hypoxia, Sedative use, Hypoglycemia, Hepatic or portal vein thrombosis, Acute hepatic failure, Portacaval shunt

Investigation Techniques for Hepatic Encephalopathy

Liver Function Test, Serum glucose, Coagulation profile, Urine culture, Blood culture, Urine toxin screen, Ultrasonography, Psychometric tests, Head CT scan

Treatment and Prevention of Hepatic Encephalopathy

Supportive care, Reversal of precipitating factors, Lactulose, Antibiotic monotherapy or rifaximin

Available Hepatic Encephalopathy Medicines

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