Paget’s Disease
Overview of Paget’s Disease
Paget’s disease is a condition where the normal cycle of an old bone tissue been replaced by the new ones are disrupted causing bones to become fragile and fractures over time. It commonly affects the legs, spine, pelvis and skull.
Signs and Symptoms of Paget’s Disease
Common complaint will be bone pain, Hip pain, Headaches, Hearing loss, Tingling & numbness in arm or leg, Bending of leg causing bowleg appearance
Common Causes of Paget’s Disease
Environmental factors, Genetic factors , Viral infection in bone cells
Risk Factors of Paget’s Disease
Age- People older than 40 are most likely to develop Paget’s disease of bone, Sex- Men are more commonly affected than are women, National origin- Paget’s disease of bone is more common in England, Scotland, central Europe and Greece, Family history.-More likely to develop the condition if you have a relative who has Paget’s disease of bone
Investigation Techniques for Paget’s Disease
Lab Test (elevated levels of alkaline phosphatase), X-rays, Bone scan, Serum marker for bone formation [Procollagen I N -terminal peptide (PINP)]
Treatment and Prevention of Paget’s Disease
Alendronate (Fosamax), Ibandronate(Boniva), Pamidronate(Aredia), Risedronate(Actonel), Zoledronic acid(Zometa, Reclast) In rare cases, surgery might be required too
Available Paget’s Disease Medicines
No medicines currently available for this condition.
