Duopharma Spiro 25mg Tablet

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Manufacturer Duopharma
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Duopharma Spiro 25mg Tablet is a prescription-only medicine (POM) presented as a tablet, with Spironolactone 25mg as its active ingredient content.

This page is limited to product, safety and handling information, in line with Malaysian rules on prescription medicine information for the public. Your prescriber or pharmacist is the right source for anything beyond that, together with the leaflet inside the pack.

Through DoctorOnCall, this product is supplied after an online consultation with a licensed doctor and a valid prescription, and it is checked by a registered pharmacist before dispensing. Take it exactly as prescribed, and speak to your doctor before stopping, changing the dose, or starting any other medicine alongside it.

Directions for Use

Take Duopharma Spiro 25mg Tablet with food to reduce stomach upset, at the same time(s) each day as directed by your doctor. Swallow the tablet whole with a glass of water. Avoid potassium supplements or salt substitutes containing potassium unless your doctor has specifically told you to use them.

Dosage

The usual starting dose of Duopharma Spiro 25mg Tablet for fluid retention or heart failure is typically 25-100mg daily in divided or single doses, adjusted by your doctor based on your response and blood test results. Dosing for hormonal indications differs and is individualised by your doctor. Always take exactly as prescribed.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Dizziness or light-headedness
  • Increased urination
  • High potassium levels (hyperkalemia)
  • Breast tenderness or enlargement
  • Irregular menstrual periods
  • Nausea or stomach upset
  • Fatigue or weakness

Contraindications

  • Known hypersensitivity to spironolactone or any ingredient in this product
  • Hyperkalaemia (high blood potassium) or significant kidney impairment
  • Addison’s disease (adrenal insufficiency)
  • Concurrent use with other potassium-sparing diuretics without medical supervision

Drug / Food Interactions

  • ACE inhibitors or ARBs (e.g. lisinopril, losartan) increase the risk of high blood potassium when combined with spironolactone
  • Potassium supplements or salt substitutes containing potassium should be avoided unless directed by your doctor
  • NSAIDs (e.g. ibuprofen) may reduce the diuretic effect and increase potassium levels
  • Lithium levels may increase when combined with spironolactone

Quick Tips

  • Avoid potassium supplements and potassium-containing salt substitutes unless your doctor directs otherwise
  • Attend scheduled blood tests to monitor your potassium levels and kidney function
  • Take with food to reduce stomach upset
  • Report any breast tenderness, enlargement, or menstrual changes to your doctor
  • Do not stop this medicine abruptly, especially if used for heart failure, without medical advice

Ingredients / Active Ingredients

  • Spironolactone 25mg

Safety Advice

Pregnancy

Not Advisable

Use during pregnancy is generally not recommended unless absolutely necessary.

Breastfeeding

Use With Care

Use with caution. Monitor infant for potential adverse reactions.

Kidney

Generally Safe

Generally safe, but caution may be required in some patients.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Not Advisable

It is not advisable to consume alcohol while taking this medicine.

Driving

Not Advisable

It is not advisable to drive if you experience side effects from this medicine.

Frequently Asked Questions

Product Specifications

BrandDuopharma
ManufacturerDuopharma
ClassificationPrescription medicine
Ingredients / Active IngredientsSpironolactone
Pack Size10s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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